ArticleComparative medicine2013
Effects of chemically induced ovarian failure on voluntary wheel-running exercise and cardiac adaptation in mice.
Article in Comparative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Animal Models of Exercise and Cardiometabolic Disease.Circulation research · 2025Review
- Myocardial transcriptomic and proteomic landscapes across the menopausal continuum in a murine model of chemically induced accelerated ovarian failure.Physiological genomics · 2025Article
- An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency.American journal of physiology. Heart and circulatory physiology · 2025Article
- Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Altered brain rhythms and behaviour in the accelerated ovarian failure mouse model of human menopause.Brain communications · 2022Article
- Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging.Aging and cancer · 2021Article
- Using 4-vinylcyclohexene diepoxide as a model of menopause for cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2020Article
- Cardiac changes during the peri-menopausal period in a VCD-induced murine model of ovarian failure.Acta physiologica (Oxford, England) · 2019Article
- The clinical impact of estrogen loss on cardiovascular disease in menopausal females.Medical research archives · 2018Article
- Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.Cell metabolism · 2017Review
- The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome.Physiology (Bethesda, Md.) · 2016Review
- Diet and sex modify exercise and cardiac adaptation in the mouse.American journal of physiology. Heart and circulatory physiology · 2015Article
- A method to study the impact of chemically-induced ovarian failure on exercise capacity and cardiac adaptation in mice.Journal of visualized experiments : JoVE · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The role of exercise in decreasing the risk of cardiovascular disease in postmenopausal women has not been studied sufficiently. Accordingly, we investigated the effect of voluntary wheel-running and forced treadmill exercise on cardiac adaptation in mice treated with 4-vinylcyclohexine diepoxide (VCD), which selectively accelerates the loss of primary and primordial follicles and results in a state that closely mimics human menopause. Two-month-old female C57BL/6 mice injected with VCD (160 mg/kg) for 20 consecutive days underwent ovarian failure by 60 to 90 d after injection. Responses to voluntary wheel running and treadmill exercise did not differ between VCD- and vehicle-treated 7-mo-old C57BL/6 or outbred B6C3F1 mice. Moreover, adaptive cardiac hypertrophy, hypertrophic marker expression, and skeletal muscle characteristics after voluntary cage-wheel exercise did not differ between VCD- and vehicle-treated mice. Because 5' AMP-activated protein kinase (AMPK) is a key component for the maintenance of cardiac energy balance during exercise, we determined the effect of exercise and VCD-induced ovarian failure on the AMPK signaling axis in the heart. According to Western blotting, VCD treatment followed by voluntary cage-wheel exercise differently affected the upstream AMPK regulatory components AMPKα1 and AMPKα2. In addition, net downstream AMPK signaling was reduced after VCD treatment and exercise. Our data suggest that VCD did not affect exercise-induced cardiac hypertrophy but did alter cellular cardiac adaptation in a mouse model of menopause.
Indexed as
Identifiers
23759526PMC3690429W1527793811What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.