ArticleThe Lancet. Infectious diseases2013
Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study.
Article in The Lancet. Infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pathways of TB Transmission in Children-A Systematic Review of Molecular Epidemiological Studies.International journal of environmental research and public health · 2023Pooled it
- Multidrug-resistant tuberculosis clusters and transmission in Taiwan: a population-based cohort study.Frontiers in microbiology · 2024Article
- Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.Frontiers in cellular and infection microbiology · 2024Article
- Multidrug-Resistant Tuberculosis in U.S.-Bound Immigrants and Refugees.Annals of the American Thoracic Society · 2022Article
- Knowledge of multidrug-resistant tuberculosis amongst Durban University of Technology students in KwaZulu-Natal, South Africa: the need for integrating public health education.African health sciences · 2022Article
- Transmission of multidrug-resistant tuberculosis in Beijing, China: An epidemiological and genomic analysis.Frontiers in public health · 2022Article
- Extensive global movement of multidrug-resistantThorax · 2019Article
- Genetic diversity of drug resistant Mycobacterium Tuberculosis in local area of Southwest China: a retrospective study.BMC infectious diseases · 2018Article
- Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017Article
- Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and epidemiological investigation.The Lancet. Infectious diseases · 2017Observational
- Article
- Transmission of Mycobacterium tuberculosis in China: a population-based molecular epidemiologic study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Origin and proliferation of multiple-drug resistance in bacterial pathogens.Microbiology and molecular biology reviews : MMBR · 2015Review
- A close-up on the epidemiology and transmission of multidrug-resistant tuberculosis in Poland.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMultidrug-resistant (MDR) tuberculosis is a potential threat to tuberculosis elimination, but the extent of MDR tuberculosis disease in the USA that is attributable to transmission within the country is unknown. We assessed transmission of MDR tuberculosis and potential contributing factors in the USA.
methodsIn a cross-sectional study, clinical, demographic, epidemiological, and Mycobacterium tuberculosis genotype data were obtained during routine surveillance of all verified cases of MDR tuberculosis reported from eight states in the USA (California from Jan 1, 2007, to Dec 31, 2009; Texas from Jan 1, 2007, to March 31, 2009; and the states of Colorado, Maryland, Massachusetts, New York, Tennessee, and Washington from Jan 1, 2007 to Dec 31, 2008). In-depth interviews and health-record abstraction were done for all who consented to ascertain potential interpersonal connections.
findings168 cases of MDR tuberculosis were reported in the eight states during our study period. 92 individuals (55%) consented to in-depth interview. 20 (22%) of these individuals developed MDR tuberculosis as a result of transmission in the USA; a source case was identified for eight of them (9%). 20 individuals (22%) had imported active tuberculosis (ie, culture-confirmed disease within 3 months of entry into the USA). 38 (41%) were deemed to have reactivation of disease, of whom 14 (15%) had a known previous episode of tuberculosis outside the USA. Five individuals (5%) had documented treatment of a previous episode in the USA, and so were deemed to have relapsed. For nine cases (10%), insufficient evidence was available to definitively classify reason for presentation.
interpretationAbout a fifth of cases of MDR tuberculosis in the USA can be linked to transmission within the country. Many individuals acquire MDR tuberculosis before entry into the USA. MDR tuberculosis needs to be diagnosed rapidly to reduce potential infectious periods, and clinicians should consider latent tuberculosis infection treatment-tailored to the results of drug susceptibility testing of the putative source case-for exposed individuals.
fundingCenters for Disease Control and Prevention.
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