ArticleJournal of affective disorders2013
Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor.
Article in Journal of affective disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors.Pharmacology, biochemistry, and behavior · 2019Pooled it
- The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor.Psychiatry research · 2022Trial
- Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.Neuropharmacology · 2017Trial
- Amphetamine increases activity but not exploration in humans and mice.Psychopharmacology · 2016Trial
- Predicting Affective Episodes in Bipolar Disorder Using Statistical Process Control Analysis of GPS-Based Mobility Patterns: Quantitative Study.JMIR mHealth and uHealth · 2026Article
- Quantifying Exploratory Behavior In The Human Behavioral Pattern Monitor Using Automated Video Tracking.Methods in Psychology (Online) · 2025Article
- A Computational Ethology Approach for Characterizing Behavioral Dynamics in Bipolar Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Article
- A Pilot Assessment of the Effects of HIV and Methamphetamine Dependence on Socially Dysregulated Behavior in the Human Behavioral Pattern Monitor.AIDS and behavior · 2023Article
- Short-active photoperiod gestation induces psychiatry-relevant behavior in healthy mice but a resiliency to such effects are seen in mice with reduced dopamine transporter expression.Scientific reports · 2020Article
- Identity in bipolar disorder: Self-worth and achievement.Journal of personality · 2020Review
- ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.Journal of neuroinflammation · 2018Article
- Similar Neural Correlates of Planning and Execution to Inhibit Continuing Actions.Frontiers in neuroscience · 2018Article
- Cortical inhibition in symptomatic and remitted mania compared to healthy subjects: A cross-sectional study.Bipolar disorders · 2017Article
- Blockade of dopamine DJournal of psychopharmacology (Oxford, England) · 2017Article
- Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania.Psychopharmacology · 2017Article
- Commonalities in EEG Spectral Power Abnormalities Between Women With ADHD and Women With Bipolar Disorder During Rest and Cognitive Performance.Brain topography · 2016Article
- Diagnosis and characterization of mania: Quantifying increased energy and activity in the human behavioral pattern monitor.Psychiatry research · 2016Article
- Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.BMC psychology · 2016Article
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundBipolar disorder (BD) is associated with inhibitory deficits characterized by a reduced ability to control inappropriate actions or thoughts. While aspects of inhibition such as exaggerated novelty-seeking and perseveration are quantified in rodent exploration of novel environments, similar models are rarely applied in humans. The human Behavioral Pattern Monitor (hBPM), a cross-species exploratory paradigm, has identified a pattern of impaired inhibitory function in manic BD participants, but this phenotype has not been examined across different BD phases. The objective of this study was to determine if euthymic BD individuals demonstrate inhibitory deficits in the hBPM, supporting disinhibition as an endophenotype for the disorder.
methods25 euthymic BD outpatients and 51 healthy comparison subjects were assessed in the hBPM, where activity was recorded by a concealed videocamera and an ambulatory monitoring sensor.
resultsEuthymic BD individuals, similar to manic subjects, demonstrated increased motor activity, greater interaction with novel objects, and more frequent perseverative behavior relative to comparison participants. The quantity of locomotion was also reduced in BD individuals treated with mood stabilizers compared to other patients. LIMITATIONS: Low sample size for treatment subgroups limits the evaluation of specific medication regimens.
conclusionsOur results suggest that BD is distinguished by both trait- and state-dependent inhibitory deficits optimally assessed with sophisticated multivariate measures. These data support the use of the hBPM as a tool to elucidate the effects of BD across various illness states, facilitate the development of BD animal models, and advance our understanding of the neurobiology underlying the disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.