ReviewClinical oncology (Royal College of Radiologists (Great Britain))2013
Focal therapy for prostate cancer: rationale and treatment opportunities.
Review in Clinical oncology (Royal College of Radiologists (Great Britain)), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- The Safety and Efficacy of Vascular-Targeted Photodynamic Therapy in Low-Risk Prostate Cancer.Cancers · 2025Article
- The use of focal therapy for the treatment of prostate cancer in Canada Where are we, how did we get here, and where are we going?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Review
- Prostate Cancer and the Rise of Focal Laser Therapies: A Narrative Review of Benefits and Limitations.Journal of lasers in medical sciences · 2025Review
- Photodynamic therapy for the precise treatment of localized prostate cancer.Frontiers in oncology · 2025Review
- Review
- Gold nanoshells for prostate cancer treatment: evidence for deposition in abdominal organs.Abdominal radiology (New York) · 2024Article
- The Trial within Cohorts (TwiCs) study design in oncology: experience and methodological reflections.BMC medical research methodology · 2023Article
- High-Frequency Pulsed Electric Field Ablation in Beagle Model for Treatment of Prostate Cancer.Cancers · 2022Article
- Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate.Scientific reports · 2021Article
- Interventional therapy in malignant conditions of the prostate.Der Radiologe · 2019Review
- Photodynamic therapy for prostate cancer: a systematic review and meta-analysis.Prostate international · 2019Review
- Focal therapy for localized prostate cancer: is there a "middle ground" between active surveillance and definitive treatment?Asian journal of andrology · 2018Article
- Focal Ablation of Prostate Cancer.Reviews in urology · 2018Article
- Poor standard mp-MRI and routine biopsy fail to precisely predict intraprostatic tumor localization.World journal of urology · 2016Article
- Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells.British journal of cancer · 2015Article
- Focal therapy: patients, interventions, and outcomes--a report from a consensus meeting.European urology · 2015Article
- [Focal therapy for prostate cancer: German version].Der Urologe. Ausg. A · 2015Review
- Low temperature plasma: a novel focal therapy for localized prostate cancer?BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Focal therapy is an emerging treatment modality for localised prostate cancer that aims to reduce the morbidity seen with radical therapy, while maintaining cancer control. Focal therapy treatment strategies minimise damage to non-cancerous tissue, with priority given to the sparing of key structures such as the neurovascular bundles, external sphincter, bladder neck and rectum. There are a number of ablative technologies that can deliver energy to destroy cancer cells as part of a focal therapy strategy. The most widely investigated are cryotherapy and high-intensity focussed ultrasound. Existing radical therapies, such as brachytherapy and external beam radiotherapy, also have the potential to be applied in a focal manner. The functional outcomes of focal therapy from several phase I and II trials have been encouraging, with low rates of urinary incontinence and erectile dysfunction. Robust medium- and long-term cancer control outcomes are currently lacking. Controversies in focal therapy remain, notably treatment paradigms based on the index lesion hypothesis, appropriate patient selection for focal therapy and how the efficacy of focal therapy should be assessed. This review articles discusses the current status of focal therapy, highlighting controversies and emerging strategies that can influence treatment outcomes for the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.