ArticleNeurobiology of aging2013
Exceptional memory performance in the Long Life Family Study.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Well-Being of the Elderly: Memory and Aging.Frontiers in psychology · 2020Pooled it
- RBFOX1 association with age at onset of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Pathway analysis of cognitive resilience factors and cognitive function in the Long Life Family Study (LLFS).Neuropsychology · 2026Observational
- Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS).Brain, behavior, & immunity - health · 2024Article
- Association between late maternal age and age-related endophenotypes in the Long Life Family Study.Neuroscience letters · 2022Article
- NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants.Journal of the International Neuropsychological Society : JINS · 2020Article
- Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.GeroScience · 2020Article
- Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.JAMA network open · 2020Observational
- Article
- A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.Metabolism: clinical and experimental · 2019Article
- The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description.European journal of epidemiology · 2018Article
- Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- A novel healthy blood pressure phenotype in the Long Life Family Study.Journal of hypertension · 2018Article
- Age-Related Biomarkers in LLFS Families With Exceptional Cognitive Abilities.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.BMC geriatrics · 2016Article
- Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging.Frontiers in immunology · 2016Review
- Article
- Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly.JAMA neurology · 2014Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ≥ 1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (β = 0.74, standard error = 0.19, p = 1.4 × 10(-4)). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.