ArticleCardiovascular diabetology2013
New concept of myocardial longitudinal strain reserve assessed by a dipyridamole infusion using 2D-strain echocardiography: the impact of diabetes and age, and the prognostic value.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Glucagon-like peptide-1 protects against ischemic left ventricular dysfunction during hyperglycemia in patients with coronary artery disease and type 2 diabetes mellitus.Cardiovascular diabetology · 2015Trial
- Global Longitudinal Strain in Stress Echocardiography: A Review of Its Diagnostic and Prognostic Role in Noninvasive Cardiac Assessment.Diagnostics (Basel, Switzerland) · 2025Review
- Analysis of Factors Related to Early Left Ventricular Dysfunction in Hypertensive Patients with Preserved Ejection Fraction Using Speckle Tracking Echocardiography: A Cross-Sectional Study in Vietnam.Diagnostics (Basel, Switzerland) · 2025Article
- Association between diabetic nephropathy and left ventricular longitudinal myocardial function in type 1 diabetes mellitus patients with preserved ejection fraction.The international journal of cardiovascular imaging · 2022Article
- Additive effects of type 2 diabetes and metabolic syndrome on left ventricular torsion and linear deformation abnormalities during dobutamine stress echocardiography.Frontiers in cardiovascular medicine · 2022Article
- Effect of heart rate on left ventricular longitudinal myocardial function in type 2 diabetes mellitus.Cardiovascular diabetology · 2021Article
- Multilayer global longitudinal strain assessment of subclinical myocardial dysfunction related to insulin resistance.The international journal of cardiovascular imaging · 2021Article
- Echocardiographic Normal Reference of Left Ventricular Contractile Reserve During Treadmill Exercise Stress Echocardiography in Healthy Chinese Adults - New Non-Sex-Specific Parameter for Left Ventricular Contractile Reserve Evaluation.International journal of general medicine · 2021Article
- Reliability and reproducibility of cardiac MRI quantification of peak exercise function with long-axis views.PloS one · 2021Article
- Myocardial strain indices and coronary flow reserve are only mildly affected in healthy hypertensive patients.The international journal of cardiovascular imaging · 2021Article
- Impact of diabetes mellitus on left ventricular longitudinal function of patients with non-ischemic dilated cardiomyopathy.Cardiovascular diabetology · 2020Article
- Utility of strain imaging in conjunction with heart failure stage classification for heart failure patient management.Journal of echocardiography · 2019Review
- Future Perspectives for Management of Stage A Heart Failure.Journal of atherosclerosis and thrombosis · 2018Article
- Potential impact of SGLT2 inhibitors on left ventricular diastolic function in patients with diabetes mellitus.Heart failure reviews · 2018Review
- Impact of overweight on left ventricular function in type 2 diabetes mellitus.Cardiovascular diabetology · 2017Article
- Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study.Journal of diabetes research · 2016Article
- Assessment of dipyridamole stress echocardiography for risk stratification of diabetic patients.Cardiovascular ultrasound · 2015Article
- Gated blood pool SPECT: The estimation of right ventricular volume and function is algorithm dependent in a clinical setting.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Observational
- Clinical features of subclinical left ventricular systolic dysfunction in patients with diabetes mellitus.Cardiovascular diabetology · 2015Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough dipyridamole is a widely used pharmacological stress agent, the direct effects on myocardium are not entirely known. Diabetic cardiomyopathy can be investigated by 2D-strain echocardiography. The aim of this study was to assess myocardial functional reserve after dipyridamole infusion using speckle-tracking echocardiography.
methodsSeventy-five patients referred for dipyridamole stress myocardial perfusion gated SPECT (MPGS) were examined by echocardiography to assess a new concept of longitudinal strain reserve (LSR) and longitudinal strain rate reserve (LSRR) respectively defined by the differences of global longitudinal strain (GLS) and longitudinal strain rate between peak stress after dipyridamole and rest. Twelve patients with myocardial ischemia were excluded on the basis of MPGS as gold standard.
resultsMean LSR was -2.28±2.19% and was more important in the 28 (44%) diabetic patients (-3.27±1.93%; p=0.001). After multivariate analyses, only diabetes improved LSR (p=0.011) after dipyridamole infusion and was not associated with glycaemic control (p=0.21), insulin therapy (p=0.46) or duration of the disease (p=0.80). Conversely, age (p=0.002) remained associated with a decrease in LSR. LSSR was also correlated to age (p=0.005). Patients with a LSR<0% have a better survival after 15 months (log-rank p=0.0012).
conclusionLSR explored by 2D speckle-tracking echocardiography after dipyridamole infusion is a simple and new concept that provides new insights into the impact of diabetes and age on the myocardium with a potential prognostic value.
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