ArticleMolecular brain2013
Repair of astrocytes, blood vessels, and myelin in the injured brain: possible roles of blood monocytes.
Article in Molecular brain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Diabetes reprograms brain and systemic immune landscapes to impair repair after injury.Molecular brain · 2026Article
- Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Systemic inflammation attenuates the repair of damaged brains through reduced phagocytic activity of monocytes infiltrating the brain.Molecular brain · 2024Article
- Integrative analysis of TBI data reveals Lgmn as a key player in immune cell-mediated ferroptosis.BMC genomics · 2023Article
- Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage.Current research in neurobiology · 2022Review
- Nitric Oxide in Selective Cerebral Perfusion Could Enhance Neuroprotection During Aortic Arch Surgery.Frontiers in cardiovascular medicine · 2021Article
- Cellular infiltration in traumatic brain injury.Journal of neuroinflammation · 2020Review
- Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum.Molecular brain · 2020Article
- Proteomic Analysis of the Breast Cancer Brain Metastasis Microenvironment.International journal of molecular sciences · 2019Article
- Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.Molecular neurodegeneration · 2019Article
- Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke.Journal of neuroinflammation · 2018Article
- Astrocytes, Microglia, and Parkinson's Disease.Experimental neurobiology · 2018Review
- Article
- GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma.Journal of neuroinflammation · 2017Article
- In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response.Journal of neuroinflammation · 2016Article
- PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes.Molecular brain · 2016Article
- Mesenchymal stromal cell therapy attenuated lung and kidney injury but not brain damage in experimental cerebral malaria.Stem cell research & therapy · 2015Article
- Microglia of prefrontal white matter in suicide.Journal of neuropathology and experimental neurology · 2014Article
- Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation.Disease models & mechanisms · 2014Article
- Astrogliosis is a possible player in preventing delayed neuronal death.Molecules and cells · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation in injured tissue has both repair functions and cytotoxic consequences. However, the issue of whether brain inflammation has a repair function has received little attention. Previously, we demonstrated monocyte infiltration and death of neurons and resident microglia in LPS-injected brains (Glia. 2007. 55:1577; Glia. 2008. 56:1039). Here, we found that astrocytes, oligodendrocytes, myelin, and endothelial cells disappeared in the damage core within 1-3 d and then re-appeared at 7-14 d, providing evidence of repair of the brain microenvironment. Since round Iba-1+/CD45+ monocytes infiltrated before the repair, we examined whether these cells were involved in the repair process. Analysis of mRNA expression profiles showed significant upregulation of repair/resolution-related genes, whereas proinflammatory-related genes were barely detectable at 3 d, a time when monocytes filled injury sites. Moreover, Iba-1+/CD45+ cells highly expressed phagocytic activity markers (e.g., the mannose receptors, CD68 and LAMP2), but not proinflammatory mediators (e.g., iNOS and IL1β). In addition, the distribution of round Iba-1+/CD45+ cells was spatially and temporally correlated with astrocyte recovery. We further found that monocytes in culture attracted astrocytes by releasing soluble factor(s). Together, these results suggest that brain inflammation mediated by monocytes functions to repair the microenvironment of the injured brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.