ReviewCritical care (London, England)2013
Intensive care sedation: the past, present and the future.
Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Propofol and survival: an updated meta-analysis of randomized clinical trials.Critical care (London, England) · 2023Pooled it
- Sedation of mechanically ventilated adults in intensive care unit: a network meta-analysis.Scientific reports · 2017Pooled it
- Assessment of Knowledge, Attitude, Practice and Associated Factors Towards Sedation Among Nurses Working in Intensive Care Units of Comprehensive Specialized Hospitals: A Multicentre Cross-Sectional Study.Nursing research and practice · 2026Article
- Sedation Practice in Intensive Care Evaluation, SPICE and beyond, Rinaldo's legacy in sedation and delirium research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Costs and Arising Work Times of Volatile Short-Term Sedation in Intensive Care.Healthcare (Basel, Switzerland) · 2025Article
- Ketamine sedation in critically ill patients: Past, present and future.Indian journal of anaesthesia · 2024Article
- Article
- Inhaled Anesthetics for Sedation in ICU: Widening Horizons!Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Sedation protocols in the pediatric intensive care unit: fact or fiction?Translational pediatrics · 2021Review
- Selection strategy for sedation depth in critically ill patients on mechanical ventilation.BMC medical informatics and decision making · 2021Article
- Comparative Effectiveness of Midazolam, Propofol, and Dexmedetomidine in Patients With or at Risk for Acute Respiratory Distress Syndrome: A Propensity Score-Matched Cohort Study.Frontiers in pharmacology · 2021Article
- Factors associated with ABCDE bundle adherence in critically ill adults requiring mechanical ventilation: An observational design.Intensive & critical care nursing · 2020Article
- Article
- Sedating critically ill patients.Singapore medical journal · 2020Article
- The ED-SED Study: A Multicenter, Prospective Cohort Study of Practice Patterns and Clinical Outcomes Associated With Emergency Department SEDation for Mechanically Ventilated Patients.Critical care medicine · 2019Article
- Effects of dexmedetomidine on delirium and mortality during sedation in ICU patients: a systematic review and meta-analysis protocol.BMJ open · 2019Article
- Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.Critical care medicine · 2019Article
- Interpersonal touch interventions for patients in intensive care: A design-oriented realist review.Nursing open · 2019Review
- Challenges of pain management in neurologically injured patients: systematic review protocol of analgesia and sedation strategies for early recovery from neurointensive care.Systematic reviews · 2018Article
- Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study.Annals of intensive care · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the universal prescription of sedative drugs in the intensive care unit (ICU), current practice is not guided by high-level evidence. Landmark sedation trials have made significant contributions to our understanding of the problems associated with ICU sedation and have promoted changes to current practice. We identified challenges and limitations of clinical trials which reduced the generalizability and the universal adoption of key interventions. We present an international perspective regarding current sedation practice and a blueprint for future research, which seeks to avoid known limitations and generate much-needed high-level evidence to better guide clinicians' management and therapeutic choices of sedative agents.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.