ArticleBMC veterinary research2013
Parity-dependent association between TNF-α and LTF gene polymorphisms and clinical mastitis in dairy cattle.
Article in BMC veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance.Genetics, selection, evolution : GSE · 2024Pooled it
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- An investigation of antioxidative and anti-inflammatory effects ofJournal of advanced veterinary and animal research · 2024Article
- Candidate genes for mastitis resistance in dairy cattle: a data integration approach.Journal of animal science and biotechnology · 2023Article
- Identification of novel alternative splicing associated with mastitis disease in Holstein dairy cows using large gap read mapping.BMC genomics · 2022Article
- Assessment of the variability of reproductive abilities of a black and white cattle using genealogical data and paratypical factors.Data in brief · 2021Article
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- Discovery of Genomic Characteristics and Selection Signatures in Southern Chinese Local Cattle.Frontiers in genetics · 2020Article
- Genome-Wide Association Study for Susceptibility to and Recoverability From Mastitis in Danish Holstein Cows.Frontiers in genetics · 2018Article
- Differential response of immune-related genes to peptidoglycan and lipoteichoic acid challengeVeterinary world · 2016Article
- Relationship of bovine TNF-α gene polymorphisms with the risk of bovine tuberculosis in Holstein cattle.The Journal of veterinary medical science · 2016Article
- Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne major problem in dairy cattle husbandry is the prevalence of udder infections. In today's breeding programmes, top priority is being given to making animal evaluation more cost-effective and reliable and less time-consuming. We proposed tumor necrosis factor α (TNF-α), lactoferrin (LTF) and macrophage-expressed lysozyme (mLYZ) genes as potential DNA markers in the improvement of immunity to mastitis.This study included 588 Polish Holstein-Friesian cows kept on one farm located in the north-western region of Poland. All clinical cases of mastitis in the herd under study were recorded by a qualified veterinarian employed by the farm. The following indicators were applied to determine udder immunity to mastitis in the cows under study: morbidity rate (MR), duration of mastitis (DM) and extent of mastitis (EM). TNF-α, mLYZ and LTF genotypes were identified by real-time PCR method, using SimpleProbe technology. Due to the very low frequency of mLYZ allele T, the gene was excluded from further analysis.A statistical analysis of associations between TNF-α and LTF genes and immunity to mastitis were performed using three models: 1) a parity-averaged model including only additive effects of the genes; 2) a parity-averaged model including both additive and epistatic effects of the genes; and 3) a parity-specific model including only additive effects of the genes.
resultsWith the first and second models it was revealed that the genes effects on the applied indicators of immunity to mastitis were non-significant whereas with the third one the effects were found to be statistically significant. Particularly noteworthy was the finding that the effects of TNF-α and LTF varied depending on age (parity). The alleles which were linked to high immunity to mastitis in lower parities appeared to be less favourable in higher parities.
conclusionsThese interactions might be related to inflamm-ageing, that is an increased susceptibility to infection due to immune system deregulation that progresses with age. Such pattern of interactions makes it impossible to use the genes in question in marker-assisted selection aimed at reducing heritable susceptibility to mastitis. This is because the immune mechanisms behind resistance to infections proved to be too complex.
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