ArticleLiver international : official journal of the International Association for the Study of the Liver2013
Healthcare utilization in chronic liver disease: the importance of pain and prescription opioid use.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- A tailored pain self-management intervention for patients with cirrhosis is acceptable and improves pain control.Hepatology communications · 2026Article
- Navigating Chronic Pain in Patients with Cirrhosis: Unique Analgesic Considerations and Non-Pharmacologic Options.Current hepatology reports · 2026Review
- Using Intervention Mapping to Develop a Novel Pain Self-Management Intervention for People with Cirrhosis.Digestive diseases and sciences · 2022Article
- AASLD Practice Guidance: Palliative care and symptom-based management in decompensated cirrhosis.Hepatology (Baltimore, Md.) · 2022Article
- Medication Treatment of Active Opioid Use Disorder in Veterans With Cirrhosis.The American journal of gastroenterology · 2021Article
- Why do patients with chronic hepatitis C drink alcohol? An examination of pain, depression and drinking motives.Journal of viral hepatitis · 2021Article
- Characteristics of opioid prescribing to outpatients with chronic liver diseases: A call for action.PloS one · 2021Article
- Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway.Public health in practice (Oxford, England) · 2020Article
- A scoping review to identify and map the multidimensional domains of pain in adults with advanced liver disease.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Underutilization of Hospice in Inpatients with Cirrhosis: The NACSELD Experience.Digestive diseases and sciences · 2020Article
- Opioid Analgesics Do Not Improve Abdominal Pain or Quality of Life in Crohn's Disease.Digestive diseases and sciences · 2020Article
- In inpatients with cirrhosis opioid use is common and associated with length of stay and persistent use post-discharge.PloS one · 2020Article
- Article
- Characteristics of Opioid Prescriptions to Veterans With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019Article
- Opioid and benzodiazepine prescription among patients with cirrhosis compared to other forms of chronic disease.BMJ open gastroenterology · 2019Article
- Pain management in patients with cirrhosis.Clinical liver disease · 2018Review
- The assessment and management of pain in cirrhosis.Current hepatology reports · 2018Article
- Patient Views on Advance Care Planning in Cirrhosis: A Qualitative Analysis.Canadian journal of gastroenterology & hepatology · 2018Article
- Risk factors for hospitalizations among patients with cirrhosis: A prospective cohort study.PloS one · 2017Article
- A Rapid Bedside Screen to Predict Unplanned Hospitalization and Death in Outpatients With Cirrhosis: A Prospective Evaluation of the Clinical Frailty Scale.The American journal of gastroenterology · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
BACKGROUND &
aimsThe aim of this study was to assess factors associated with healthcare utilization in patients with chronic liver disease with a focus on pain, opioid use and psychiatric symptoms.
methodsWe retrospectively assessed a consecutive sample of 1286 visitors to a hepatology clinic with chronic liver disease. Baseline psychiatric symptoms, pain and opioid prescriptions were collected. Liver-related clinic visits, total clinic visits, phone calls and hospitalizations were assessed over a subsequent 6-month period. Multivariable logistic and negative binomial regression models were used to determine the medical and psychosocial factors associated with increased healthcare utilization.
resultsOver a 6-month period, hospitalization was more common among patients with pain (13% vs. 7%, P < 0.0001) and opioid usage (18% vs. 6% P < 0.0001). Pain and opioid usage were independently and significantly associated with an increased hospitalizations and median number of clinic visits and phone calls (P < 0.0001). In multivariable modelling, hospitalization was significantly associated with opioid use (OR = 2.72, CI = 1.72, 4.29), Child's Class B (OR = 2.24, CI = 1.19, 4.14) and C (OR = 8.51, CI = 4.18, 17.27) cirrhosis, and cardiopulmonary disease (OR = 2.11, CI = 1.28, 3.41). Pain and opioid usage were independently and significantly associated with the numbers of phone calls and total outpatient visits, as were medical comorbidities and Child's Class. The significant predictors of increased outpatient liver-related visits were pain (IRR = 1.13, CI = 1.02, 1.26), interferon usage (IRR = 1.75, CI = 1.54, 1.98) and more advanced liver disease (IRR = 1.58, CI = 1.32, 1.88).
conclusionsPain and prescription opioid usage were significantly linked to increased healthcare utilization, suggesting the need to evaluate and incorporate evidence-based pain management strategies into routine care of patients with chronic liver disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.