SynthesisBMC pulmonary medicine2013
Effect of physical training on airway inflammation in bronchial asthma: a systematic review.
Synthesis in BMC pulmonary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Effects of Physical Exercises in Asthma: An Umbrella Review of Systematic Review and Meta-Analysis.The clinical respiratory journal · 2025Pooled it
- A Systematic Review of the Effect of Physical Activity on Asthma Outcomes.The journal of allergy and clinical immunology. In practice · 2021Pooled it
- Effects of exercise-based pulmonary rehabilitation on adults with asthma: a systematic review and meta-analysis.Respiratory research · 2021Pooled it
- Effect of physical training on airway inflammation in animal models of asthma: a systematic review.BMC pulmonary medicine · 2013Pooled it
- Winter Exercise Reduces Allergic Airway Inflammation: A Randomized Controlled Study.International journal of environmental research and public health · 2019Trial
- Trial
- Active Video Game Exercise Training Improves the Clinical Control of Asthma in Children: Randomized Controlled Trial.PloS one · 2015Trial
- Asthma-related lung function and physical activity patterns among children living in urban neighborhoods.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Oxidative Stress, Environmental Pollution, and Lifestyle as Determinants of Asthma in Children.Biology · 2023Review
- Basis of preventive and non-pharmacological interventions in asthma.Frontiers in public health · 2023Review
- Effects of physical activity on lung function and quality of life in asthmatic children: An updated systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma.Antioxidants (Basel, Switzerland) · 2021Article
- COVID-19 Pandemic and Reduced Physical Activity: Is There an Impact on Healthy and Asthmatic Children?Frontiers in pediatrics · 2021Review
- Defining a role for exercise training in the management of asthma.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Effect of physical activity on asthma control in schoolchildren.Einstein (Sao Paulo, Brazil) · 2020Observational
- Evidence for lifestyle interventions in asthma.Breathe (Sheffield, England) · 2019Review
- Tai Chi Chuan Exercise Improves Lung Function and Asthma Control through Immune Regulation in Childhood Asthma.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Daily physical activity and lung function decline in adult-onset asthma: a 12-year follow-up study.European clinical respiratory journal · 2018Article
- A 12-month, moderate-intensity exercise training program improves fitness and quality of life in adults with asthma: a controlled trial.BMC pulmonary medicine · 2015Article
- Evaluation of functional, autonomic and inflammatory outcomes in children with asthma.World journal of clinical cases · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe majority of the global population cannot afford existing asthma pharmacotherapy. Physical training as an airway anti-inflammatory therapy for asthma could potentially be a non-invasive, easily available, affordable, and healthy treatment modality. However, effects of physical training on airway inflammation in asthma are currently inconclusive. The main objective of this review is to summarize the effects of physical training on airway inflammation in asthmatics.
methodsA peer reviewed search was applied to Medline, Embase, Web of Science, Cochrane, and DARE databases. We included all observational epidemiological research studies and RCTs. Studies evaluating at least one marker of airway inflammation in asthmatics after a period of physical training were selected. Data extraction was performed in a blinded fashion. We decided a priori to avoid pooling of the data in anticipation of heterogeneity of the studies, specifically heterogeneity of airway inflammatory markers studied as outcome measures.
resultsFrom the initial 2635 studies; 23 studies (16 RCTs and 7 prospective cohort studies) were included. Study sizes were generally small (median sample size = 30). There was a reduction in C-reactive protein, malondialdehyde, nitric oxide, sputum cell counts and IgE in asthmatics with physical training. Mixed results were observed after training for fractional excretion of nitric oxide and bronchial hyperresponsiveness. The data was not pooled owing to significant heterogeneity between studies, and a funnel plot tests for publication bias were not performed because there were less than 10 studies for almost all outcome measures. Physical training intervention type, duration, intensity, frequency, primary outcome measures, methods of assessing outcome measures, and study designs were heterogeneous.
conclusionDue to reporting issues, lack of information and heterogeneity there was no definite conclusion; however, some findings suggest physical training may reduce airway inflammation in asthmatics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.