ArticleEnvironmental science & technology2013
Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos.
Article in Environmental science & technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 228 citations in OpenAlex.
- Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models.Advanced healthcare materials · 2026Review
- Investigation of Cell Damage Induced by Silver Nanoparticles in a Model Cell System.Pharmaceutics · 2025Article
- Green synthesized silver nanoparticles, a sustainable approach for fruit and vegetable preservation: An overview.Food chemistry: X · 2024Review
- Developmental impacts and toxicological hallmarks of silver nanoparticles across diverse biological models.Environmental science and ecotechnology · 2024Review
- Multifaceted Assessment of Porous Silica Nanocomposites: Unraveling Physical, Structural, and Biological Transformations Induced by Microwave Field Modification.Nanomaterials (Basel, Switzerland) · 2024Article
- Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles.International journal of molecular sciences · 2024Review
- Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy.Cells · 2023Review
- Zebrafish-based platform for emerging bio-contaminants and virus inactivation research.The Science of the total environment · 2023Review
- Effect of Quercetin Nanoparticles on Hepatic and Intestinal Enzymes and Stress-Related Genes in Nile Tilapia Fish Exposed to Silver Nanoparticles.Biomedicines · 2023Article
- Particle Size Modulates Silver Nanoparticle Toxicity during Embryogenesis of UrchinsInternational journal of molecular sciences · 2023Article
- Toxic Effects of Silver Ions on Early Developing Zebrafish Embryos Distinguished from Silver Nanoparticles.ACS omega · 2022Article
- Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.Journal of nanobiotechnology · 2022Article
- Low Concentrations of Silver Nanoparticles Inhibit Spore Germination and Disturb Gender Differentiation ofNanomaterials (Basel, Switzerland) · 2022Article
- Article
- Combined toxicity of polystyrene microplastics and sulfamethoxazole on zebrafish embryos.Environmental science and pollution research international · 2022Article
- Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo.Particle and fibre toxicology · 2022Article
- High throughput embryonic zebrafish test with automated dechorionation to evaluate nanomaterial toxicity.PloS one · 2022Article
- Changes of Gene Expression Patterns from Aquatic Organisms Exposed to Metal Nanoparticles.International journal of environmental research and public health · 2021Review
- Toxicological Profile of Plasmonic Nanoparticles in Zebrafish Model.International journal of molecular sciences · 2021Review
- Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo.Nanomaterials (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silver nanoparticles cause toxicity in exposed organisms and are an environmental health concern. The mechanisms of silver nanoparticle toxicity, however, remain unclear. We examined the effects of exposure to silver in nano-, bulk-, and ionic forms on zebrafish embryos (Danio rerio) using a Next Generation Sequencing approach in an Illumina platform (High-Throughput SuperSAGE). Significant alterations in gene expression were found for all treatments and many of the gene pathways affected, most notably those associated with oxidative phosphorylation and protein synthesis, overlapped strongly between the three treatments indicating similar mechanisms of toxicity for the three forms of silver studied. Changes in oxidative phosphorylation indicated a down-regulation of this pathway at 24 h of exposure, but with a recovery at 48 h. This finding was consistent with a dose-dependent decrease in oxygen consumption at 24 h, but not at 48 h, following exposure to silver ions. Overall, our data provide support for the hypothesis that the toxicity caused by silver nanoparticles is principally associated with bioavailable silver ions in exposed zebrafish embryos. These findings are important in the evaluation of the risk that silver particles may pose to exposed vertebrate organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.