Evidence map›Paper›PMID 23758122›Full record

Trial reportGenetic testing and molecular biomarkers2013

JMY polymorphism is related to severity of ankylosing spondylitis in Chinese Han patients.

Wei Chai, Zijian Lian, Chao Chen, Jingyi Liu, Lewis L Shi, Yan Wang

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Genetic testing and molecular biomarkers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Wei ChaiDepartment of Orthopedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Zijian Lian
Chao Chen
Jingyi Liu
Lewis L Shi
Yan Wang
Nankai University · CNTianjin Hospital · CNChinese General Hospital College of Nursing and Liberal Arts · PHUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is a largely genetically determined autoimmune disease. JMY has recently been found to be associated with susceptibility to AS in patients of western European descent. We aimed to examine the influence of JMY polymorphisms on the severity of AS in the Chinese ethnic majority Han population. Blood samples were drawn from 396 Chinese Han AS patients whose duration of disease was about 9-12 years. Four tag single-nucleotide polymorphisms (tagSNPs) in JMY were selected and genotyped. Frequencies of different genotypes and clinical indexes about the severity of AS were analyzed. The rs2607142, rs16876619, and rs4704556 SNPs are related to BASFI. The rs2607142, rs4704556, and rs16876657 SNPs are related to BADAI. The rs4704556 and rs16876657 SNPs are related to mSASSS. JMY is related to the severity of AS in Chinese Han patients.

Indexed as

Asian PeoplePolymorphism, Single NucleotideAdolescentAdultChinaFemaleHumansMaleMiddle AgedNuclear ProteinsSeverity of Illness IndexSpondylitis, AnkylosingTrans-ActivatorsJMY protein, humanNuclear ProteinsTrans-Activators

Identifiers

PMID23758122
PMCPMC3732413
OpenAlexW2051738002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.