ArticleACS nano2013
Threading immobilized DNA molecules through a solid-state nanopore at >100 μs per base rate.
Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Addressing the Challenges of Solid-State Nanopores: Strategies for Performance Enhancement.International journal of molecular sciences · 2026Review
- Angular-Inertia Regulated Stable and Nanoscale Sensing of Single Molecules Using Nanopore-In-A-Tube.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules.Nature communications · 2024Article
- Fast Fabrication Nanopores on a PMMA Membrane by a Local High Electric Field Controlled Breakdown.Sensors (Basel, Switzerland) · 2024Article
- Solid-State Nanopores for Biomolecular Analysis and Detection.Advances in biochemical engineering/biotechnology · 2024Review
- Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges.International journal of molecular sciences · 2023Review
- Zero-mode waveguides and nanopore-based sequencing technologies accelerate single-molecule studies.Biophysics and physicobiology · 2022Article
- Single DNA Translocation and Electrical Characterization Based on Atomic Force Microscopy and Nanoelectrodes.IEEE open journal of nanotechnology · 2022Article
- Controlling DNA Translocation Through Solid-state Nanopores.Nanoscale research letters · 2020Review
- Mechanically stable solvent-free lipid bilayers in nano- and micro-tapered apertures for reconstitution of cell-free synthesized hERG channels.Scientific reports · 2017Article
- Discrimination of three types of homopolymers in single-stranded DNA with solid-state nanopores through external control of the DNA motion.Scientific reports · 2017Article
- A tip-attached tuning fork sensor for the control of DNA translocation through a nanopore.The Review of scientific instruments · 2017Article
- Mechanical Trapping of DNA in a Double-Nanopore System.Nano letters · 2016Article
- Dielectrophoretic stretching of DNA tethered to a fiber tip.Nanotechnology · 2015Article
- Nanopore-based fourth-generation DNA sequencing technology.Genomics, proteomics & bioinformatics · 2015Review
- Membrane thickness dependence of nanopore formation with a focused helium ion beam.Sensors (Basel, Switzerland) · 2014Article
- Electrically facilitated translocation of protein through solid nanopore.Nanoscale research letters · 2014Article
- The evolution of nanopore sequencing.Frontiers in genetics · 2014Review
- A nanopore-nanofiber mesh biosensor to control DNA translocation.Journal of the American Chemical Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In pursuit of developing solid-state nanopore-based DNA sequencing technology, we have designed and constructed an apparatus that can place a DNA-tethered probe tip near a solid-state nanopore, control the DNA moving speed, and measure the ionic current change when a DNA molecule is captured and released from a nanopore. The probe tip's position is sensed and controlled by a tuning fork based feedback force sensor and a nanopositioning system. Using this newly constructed apparatus, a DNA strand moving rate of >100 μs/base or <1 nm/ms in silicon nitride nanopores has been accomplished. This rate is 10 times slower than by manipulating DNA-tethered beads using optical tweezers and 1000 times slower than free DNA translocation through solid-state nanopores reported previously, which provides enough temporal resolution to read each base on a tethered DNA molecule using available single-channel recording electronics on the market today. This apparatus can measure three signals simultaneously: ionic current through a nanopore, tip position, and tip vibrational amplitude during the process of a DNA molecule's capture and release by a nanopore. We show results of this apparatus for measuring λ DNA's capture and release distances and for current blockage signals of λ DNA molecules biotinylated with one end and with both ends tethered to a tip.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.