Evidence map›Paper›PMID 23757735›Full record

SynthesisBMJ (Clinical research ed.)2013

Antibiotic prophylaxis for urinary tract infections after removal of urinary catheter: meta-analysis.

Jonas Marschall, Christopher R Carpenter, Susan Fowler, Barbara W Trautner, CDC Prevention Epicenters Program

Erratum issued 2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00554996 phase1completednot on this map

Bacterial Interference for Prevention of Catheter-Associated UTI

TypeinterventionalSponsorUS Department of Veterans AffairsRan2012 to 2014Enrolled10ConditionsUrinary Tract InfectionArmsE. coli 83972 coated urinary catheter
NCT02358993 nacompletednot on this mapstarted 2014, after this paper: background citation

The Efficacy and Cost-effectiveness of a 24-hour Course of metheNamine Hippurate for Preventing Post-Operative Urinary Tract Infection

TypeinterventionalSponsorUniversity of PennsylvaniaRan2014 to 2020Enrolled201ConditionsUrinary Tract Infections, Catheter-Related InfectionsArmsmethenamine hippurate, Ciprofloxacin
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Perioperative fosfomycin disodium prophylaxis against urinary tract infection in renal transplant recipients: a randomized clinical trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Trial
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  11. Review
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  15. Article
  16. Catheter-Associated Urinary Tract Infections in Adult Patients.Deutsches Arzteblatt international · 2020
    Review
  17. Article
  18. Review
  19. Impact of antibiotic prophylaxis on catheter-associated urinary tract infections during atrial fibrillation ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018
    Article
  20. Surgical antimicrobial prophylaxis.Australian prescriber · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jonas MarschallDivision of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA. jmarscha@dom.wustl.edu
Christopher R Carpenter
Susan Fowler
Barbara W Trautner
CDC Prevention Epicenters Program
Washington University in St. Louis · USHealth Services Research & Development · USUniversity Hospital of Bern · CH

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTHK12HD001459 · NICHD · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2000 to 2014
$6.9M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NCEZID CDC HHS U54 CK000162NICHD NIH HHS 5K12HD001459-13PHS HHS NIDDK R21 092293
6 · The paper itself

Abstract

objectiveTo determine whether antibiotic prophylaxis at the time of removal of a urinary catheter reduces the risk of subsequent symptomatic urinary tract infection.:

designSystematic review and meta-analysis of studies published before November 2012 identified through PubMed, Embase, Scopus, and the Cochrane Library; conference abstracts for 2006-12 were also reviewed. INCLUSION CRITERIA: Studies were included if they examined antibiotic prophylaxis administered to prevent symptomatic urinary tract infection after removal of a short term (≤ 14 days) urinary catheter.

resultsSeven controlled studies had symptomatic urinary tract infection after catheter removal as an endpoint; six were randomized controlled trials (five published; one in abstract form) and one was a non-randomized controlled intervention study. Five of these seven studies were in surgical patients. Studies were heterogeneous in the type and duration of antimicrobial prophylaxis and the period of observation. Overall, antibiotic prophylaxis was associated with benefit to the patient, with an absolute reduction in risk of urinary tract infection of 5.8% between intervention and control groups. The risk ratio was 0.45 (95% confidence interval 0.28 to 0.72). The number needed to treat to prevent one urinary tract infection was 17 (12 to 30).

conclusionsPatients admitted to hospital who undergo short term urinary catheterization might benefit from antimicrobial prophylaxis when the catheter is removed as they experience fewer subsequent urinary tract infections. Potential disadvantages of more widespread antimicrobial prophylaxis (side effects and cost of antibiotics, development of antimicrobial resistance) might be mitigated by the identification of which patients are most likely to benefit from this approach.

Indexed as

Antibiotic ProphylaxisCatheters, IndwellingDevice RemovalFemaleGuidelines as TopicHumansMaleRandomized Controlled Trials as TopicUrinary CatheterizationUrinary CathetersUrinary Tract Infections

Identifiers

PMID23757735
PMCPMC3678514
OpenAlexW1983693858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.