ArticleBlood2013
Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue.
Article in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Construction of a prediction model for retinopathy of prematurity based on placenta-derived genes and clinical variables.Translational pediatrics · 2026Article
- Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024Review
- Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract.Mucosal immunology · 2023Article
- The β1 Adrenergic Blocker Nebivolol Ameliorates Development of Endotoxic Acute Lung Injury.Journal of clinical medicine · 2023Article
- Pre-Activated Granulocytes from an Autoimmune Uveitis Model Show Divergent Pathway Activation Profiles upon IL8 Stimulation In Vitro.International journal of molecular sciences · 2022Article
- Review
- Therapeutic targeting of neutrophil exocytosis.Journal of leukocyte biology · 2020Review
- Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.Frontiers in oncology · 2020Article
- Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation.Scientific reports · 2019Article
- [Recent developments in head and neck immunology : A basis for novel therapeutic strategies?]HNO · 2019Review
- In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines.Mucosal immunology · 2018Article
- Murine neutrophils treated with alphaB-crystallin reduce IL-12p40 production by dendritic cells.Immunology · 2018Article
- Oxidative modifications of extracellular matrix promote the second wave of inflammation via βBlood · 2018Article
- Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin.PLoS biology · 2017Article
- Ischemia/Reperfusion.Comprehensive Physiology · 2016Review
- Pathobiology of neutrophil-epithelial interactions.Immunological reviews · 2016Review
- Platelets Guide Leukocytes to Their Sites of Extravasation.PLoS biology · 2016Article
- Mechanism of Diapedesis: Importance of the Transcellular Route.Advances in immunology · 2016Review
- A study on quantitative structure-activity relationship and molecular docking of metalloproteinase inhibitors based on L-tyrosine scaffold.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Article
- Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration.Tissue barriers · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro studies suggest that leukocytes locomote in an ameboid fashion independently of pericellular proteolysis. Whether this motility pattern applies for leukocyte migration in inflamed tissue is still unknown. In vivo microscopy on the inflamed mouse cremaster muscle revealed that blockade of serine proteases or of matrix metalloproteinases (MMPs) significantly reduces intravascular accumulation and transmigration of neutrophils. Using a novel in vivo chemotaxis assay, perivenular microinjection of inflammatory mediators induced directional interstitial migration of neutrophils. Blockade of actin polymerization, but not of actomyosin contraction abolished neutrophil interstitial locomotion. Multiphoton laser scanning in vivo microscopy showed that the density of the interstitial collagen network increases in inflamed tissue, thereby providing physical guidance to infiltrating neutrophils. Although neutrophils locomote through the interstitium without pericellular collagen degradation, inhibition of MMPs, but not of serine proteases, diminished their polarization and interstitial locomotion. In this context, blockade of MMPs was found to modulate expression of adhesion/signaling molecules on neutrophils. Collectively, our data indicate that serine proteases are critical for neutrophil extravasation, whereas these enzymes are dispensable for neutrophil extravascular locomotion. By contrast, neutrophil interstitial migration strictly relies on actin polymerization and does not require the pericellular degradation of collagen fibers but is modulated by MMPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.