ArticleEnvironmental health perspectives2013
Fetal exposure of rhesus macaques to bisphenol a alters cellular development of the conducting airway by changing epithelial secretory product expression.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A systematic review of metabolomics biomarkers for Bisphenol A exposure.Metabolomics : Official journal of the Metabolomic Society · 2018Pooled it
- Initiation of Cancer: The Journey From Mutations in Somatic Cells to Epigenetic Changes in Tissue-resident VSELs.Stem cell reviews and reports · 2024Review
- Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum.International journal of molecular sciences · 2022Review
- Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm.Endocrinology · 2021Review
- Prenatal Bisphenol A Exposure Alters Epithelial Cell Composition in the Rhesus Macaque Fetal Oviduct.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Effects of Bisphenol A Metabolite 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene on Lung Function and Type 2 Pulmonary Alveolar Epithelial Cell Growth.Scientific reports · 2016Article
- Effects of long-term endocrine disrupting compound exposure on Macaca mulatta embryonic stem cells.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- An old culprit but a new story: bisphenol A and "NextGen" bisphenols.Fertility and sterility · 2016Review
- Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey.PloS one · 2016Article
- Women and Lung Disease. Sex Differences and Global Health Disparities.American journal of respiratory and critical care medicine · 2015Review
- Bisphenol a exposure and the development of wheeze and lung function in children through age 5 years.JAMA pediatrics · 2014Article
- Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure.Molecular and cellular endocrinology · 2014Review
- Bisphenol A exposure is associated with decreased lung function.The Journal of pediatrics · 2014Article
- Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model.PloS one · 2014Article
- Bisphenol A exposure and asthma development in school-age children: a longitudinal study.PloS one · 2014Article
- BPA and altered airway cells: association seen in rhesus macaques after third-trimester exposure.Environmental health perspectives · 2013Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBisphenol A (BPA) exposure early in life results in organizational changes in reproductive organs, but the effect of BPA on conducting airway cellular maturation has not been studied. Late gestation is characterized by active differentiation of secretory cells in the lung epithelium.
objectiveWe evaluated the hypothesis that BPA exposure disrupts epithelial secretory cell development in the fetal conducting airway of the rhesus macaque.
methodsWe exposed animals to BPA during either the second (early term) or the third (late term) trimester. There were four treatment groups: a) sham control early term, b) sham control late term, c) BPA early term (BPA-early), and d) BPA late term (BPA-late). Because cellular maturation occurs nonuniformly in the lung, we defined mRNA and protein expression by airway level using microdissection.
resultsBPA exposure of the dam during late term significantly accelerated secretory cell maturation in the proximal airways of the fetus; both Clara cell secretory protein (CCSP) and MUC5AC/5B mRNA and protein expression increased.
conclusionsBPA exposure during late gestation accelerates secretory cell maturation in the proximal conducting airways. We identified a critical window of fetal susceptibility for BPA effects on lung epithelial cell maturation in the third trimester. This is of environmental health importance because increases in airway mucins are hallmarks of a number of childhood lung diseases that may be affected by BPA exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.