Evidence map›Paper›PMID 2375749›Full record

ArticleThe Biochemical journal1990

Differences in the properties of A1-type adenosine receptors in rat white and brown adipocytes.

E D Saggerson, Z Jamal

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Purinergic signalling in endocrine organs.Purinergic signalling · 2014
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

E D SaggersonDepartment of Biochemistry, University College London, U.K.
Z Jamal
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. White adipocytes were found to be more responsive than brown adipocytes to inhibition of lipolysis by the A1 adenosine receptor agonist phenylisopropyladenosine. 2. Radioligand binding studies with plasma membranes isolated from the two adipocyte types indicated differences in the properties of the A1 receptors. Kd values (high and low affinity) for phenylisopropyladenosine were higher in membranes from brown adipocytes. The Kd values for the antagonist dipropylcyclopentylxanthine were also higher in brown adipocyte membranes. 3. The effects of guanine nucleotides in converting adipocyte A1 receptors into a low-affinity state were enhanced by dithiothreitol.

Indexed as

AdenosineAdenosine-5'-(N-ethylcarboxamide)Adipose TissueAdipose Tissue, BrownAnimalsBinding, CompetitiveCell MembraneGuanosine TriphosphateGuanylyl ImidodiphosphateLipolysisMaleNorepinephrinePhenylisopropyladenosinePurinergic AntagonistsRatsRats, Inbred Strains1,3-dipropyl-8-cyclopentylxanthineAdenosineAdenosine-5'-(N-ethylcarboxamide)Guanosine TriphosphateGuanylyl ImidodiphosphateNorepinephrinePhenylisopropyladenosinePurinergic AntagonistsReceptors, PurinergicXanthines

Identifiers

PMID2375749
PMCPMC1131545
OpenAlexW2329271834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.