ReviewIUBMB life2013
Targeting the therapeutic effects of exercise on redox-sensitive mechanisms in the vascular endothelium during tumor progression.
Review in IUBMB life, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- The antitumor mechanisms of aerobic exercise: A review of recent preclinical studies.Cancer medicine · 2021Review
- Exercise modulation of tumour perfusion and hypoxia to improve radiotherapy response in prostate cancer.Prostate cancer and prostatic diseases · 2021Review
- Effects of exercise training on breast cancer metastasis in a rat model.International journal of experimental pathology · 2017Article
- Selenoglycoproteins attenuate adhesion of tumor cells to the brain microvascular endothelium via a process involving NF-κB activation.The Journal of nutritional biochemistry · 2015Article
- Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The American Cancer Society estimated 1.5 million new cancer cases in the United States in 2012. Although the exact number is not known, it is estimated that brain metastases occur in 20-40% of cancer patients (39). Owing to the complexity of development and the variation in tumor etiology, therapy options have been limited for a number of cancers, whereas progressive treatments have been successful for some malignancies. Combining treatment strategies has shown potential to increase positive outcomes; however, cancer remains a formidable diagnosis with no true cure. Many researchers have focused on alternative forms of cancer prevention or treatment to slow cancer progression. Studies have shown that with moderate, regular exercise signaling pathways associated with increased antioxidant activity and cellular repair are upregulated in vascular tissue; however, the physiological mechanisms are poorly understood. The purpose of this review is to examine the current literature to better understand the impact of exercise on cancer progression and tumor metastasis and discuss potential redox-related signaling in the vasculature that may be involved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.