ReviewWiley interdisciplinary reviews. Systems biology and medicine
Excitable behavior in amoeboid chemotaxis.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Establishing functional giant Dictyostelium cells reveals front-rear polarity in intracellular signaling.Communications biology · 2026Article
- Cell-to-cell signaling in cell populations with large cell size variability.Biophysical journal · 2025Article
- Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration.Nature cell biology · 2024Article
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells.Journal of cell science · 2019Article
- The Use of Diffusion Calculations and Monte Carlo Simulations to Understand the Behavior of Cells inComputational and structural biotechnology journal · 2019Review
- Mutually inhibitory Ras-PI(3,4)PProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells.PloS one · 2018Article
- The threshold of an excitable system serves as a control mechanism for noise filtering during chemotaxis.PloS one · 2018Article
- Excitable Signal Transduction Networks in Directed Cell Migration.Annual review of cell and developmental biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chemotaxis, the directed motion of cells in response to chemical gradients, is a fundamental process. Eukaryotic cells detect spatial differences in chemoattractant receptor occupancy with high precision and use these differences to bias the location of actin-rich protrusions to guide their movement. Research into chemotaxis has benefitted greatly from a systems biology approach that combines novel experimental and computational tools to pose and test hypotheses. Recently, one such hypothesis has been postulated proposing that chemotaxis in eukaryotic cells is mediated by locally biasing the activity of an underlying excitable system. The excitable system hypothesis can account for a number of cellular behaviors related to chemotaxis, including the stochastic nature of the movement of unstimulated cells, the directional bias imposed by chemoattractant gradients, and the observed spatial and temporal distribution of signaling and cytoskeleton proteins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.