ArticleMolecular genetics and genomics : MGG2013
Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis.
Article in Molecular genetics and genomics : MGG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 51 citations in OpenAlex.
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Collaboration between DELLA proteins and the Mediator subunit MED15 to regulate transcription in plants.Journal of experimental botany · 2025Article
- DELLA proteins recruit the Mediator complex subunit MED15 to coactivate transcription in land plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Recent advancements in the role of histone acetylation dynamics to improve stress responses in plants.Molecular biology reports · 2024Review
- Genome-wide analysis of KIX gene family for organ size regulation in soybean (Frontiers in plant science · 2023Article
- SlKIX8 and SlKIX9 are negative regulators of leaf and fruit growth in tomato.Plant physiology · 2022Article
- A perspective on the molecular mechanism in the control of organ internal (IN) asymmetry during petal development.Horticulture research · 2022Article
- Small RNA profiling for identification of microRNAs involved in regulation of seed development and lipid biosynthesis in yellowhorn.BMC plant biology · 2021Article
- Histone acetylation dynamics regulating plant development and stress responses.Cellular and molecular life sciences : CMLS · 2021Review
- MedProDB: A database of Mediator proteins.Computational and structural biotechnology journal · 2021Article
- Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications.International journal of molecular sciences · 2020Review
- Molecular and Phylogenetic Analyses of the Mediator Subunit Genes inFrontiers in genetics · 2019Article
- KIX domain of AtMed15a, a Mediator subunit of Arabidopsis, is required for its interaction with different proteins.Plant signaling & behavior · 2018Article
- KIXBASE: A comprehensive web resource for identification and exploration of KIX domains.Scientific reports · 2017Article
- Rice Improvement Through Genome-Based Functional Analysis and Molecular Breeding in India.Rice (New York, N.Y.) · 2016Article
- The Mediator Complex MED15 Subunit Mediates Activation of Downstream Lipid-Related Genes by the WRINKLED1 Transcription Factor.Plant physiology · 2016Article
- Expression of AtMed15 of Arabidopsis in yeast causes flocculation and increases ethanol production in yeast culture.Scientific reports · 2016Article
- An Integrated Genomic Strategy Delineates Candidate Mediator Genes Regulating Grain Size and Weight in Rice.Scientific reports · 2016Article
- Evolution of disorder in Mediator complex and its functional relevance.Nucleic acids research · 2016Article
- A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.The Plant cell · 2015Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The KIX domain, which mediates protein-protein interactions, was first discovered as a motif in the large multidomain transcriptional activator histone acetyltransferase p300/CBP. Later, the domain was also found in Mediator subunit MED15, where it interacts with many transcription factors. In both proteins, the KIX domain is a target of activation domains of diverse transcription activators. It was found to be an essential component of several specific gene-activation pathways in fungi and metazoans. Not much is known about KIX domain proteins in plants. This study aims to characterize all the KIX domain proteins encoded by the genomes of Arabidopsis and rice. All identified KIX domain proteins are presented, together with their chromosomal locations, phylogenetic analysis, expression and SNP analyses. KIX domains were found not only in p300/CBP- and MED15-like plant proteins, but also in F-box proteins in rice and DNA helicase in Arabidopsis, suggesting roles of KIX domains in ubiquitin-mediated proteasomal degradation and genome stability. Expression analysis revealed overlapping expression of OsKIX_3, OsKIX_5 and OsKIX_7 in different stages of rice seeds development. Moreover, an association analysis of 136 in silico mined SNP loci in 23 different rice genotypes with grain-length information identified three non-synonymous SNP loci in these three rice genes showing strong association with long- and short-grain differentiation. Interestingly, these SNPs were located within KIX domain encoding sequences. Overall, this study lays a foundation for functional analysis of KIX domain proteins in plants.
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