ArticleNeurochemical research2013
Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes.
Article in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Polyphenols in the Central Nervous System: Cellular Effects and Liposomal Delivery Approaches.International journal of molecular sciences · 2025Review
- Anxiolytic, Antidepressant and Healthy Sleep-Promoting Potential of Rosmarinic Acid: Mechanisms and Molecular Targets.Neuropsychiatric disease and treatment · 2025Review
- In silico anti-alzheimer study of phytochemicals from Lamiaceae family through GSK3-β inhibition.Scientific reports · 2024Article
- The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-basedFrontiers in pharmacology · 2023Article
- Rosmarinic acid prevents post-operative abdominal adhesions in a rat model.Scientific reports · 2022Article
- Phenolic Acids as Antidepressant Agents.Nutrients · 2022Review
- Evaluation of rosmarinic acid against myocardial infarction in maternally separated rats.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Biomedical features and therapeutic potential of rosmarinic acid.Archives of pharmacal research · 2022Review
- Melissa officinalis L. ameliorates oxidative stress and inflammation and upregulates Nrf2/HO-1 signaling in the hippocampus of pilocarpine-induced rats.Environmental science and pollution research international · 2022Article
- The Role of Natural Products in Treatment of Depressive Disorder.Current neuropharmacology · 2022Article
- Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior.Molecular neurobiology · 2021Article
- Anxiolytic and Antidepressant-Like Effects ofPlants (Basel, Switzerland) · 2021Article
- Natural Products for Neurodegeneration: Regulating Neurotrophic Signals.Oxidative medicine and cellular longevity · 2021Review
- Effects of rosmarinic acid on nervous system disorders: an updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2020Review
- Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems.Frontiers in pharmacology · 2020Review
- Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors.Molecular neurobiology · 2019Article
- Assessment of Antidepressant Effect of the Aerial Parts ofMolecules (Basel, Switzerland) · 2019Article
- Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells.Journal of natural medicines · 2018Article
- Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects.Drugs in R&D · 2017Review
- Impact of diet-derived signaling molecules on human cognition: exploring the food-brain axis.NPJ science of food · 2017Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosmarinic acid (RA), a primary constituent of a Chinese herbal medicine, has been shown to have some therapeutic effects in an animal model of depression, but its underlying mechanisms are poorly understood. Sprague-Dawley rats were exposed to chronic unpredictable stress (CUS) for 21 days, and received RA for 14 days from the last week of CUS, then the behavioral changes, hippocampal pERK1/2 and BDNF levels were observed. Rats were further treated with U0126 (an ERK1/2 phosphorylation inhibitor) 30 min before RA treatment to assess the effects of RA and ERK1/2 signaling in depressive-like behavior and hippocampal BDNF levels. In addition, brains of newly born Sprague-Dawley rats were used to harvest and expand hippocampal astrocytes. Cells were exposed to different concentrations of RA (sham, 1, 5, 10, 20, and 40 μg/mL) or U0126 (2 μM as a final concentration) + RA (sham, 1, 5, 10, 20, and 40 μg/mL) for 48 h, and the pERK1/2 and BDNF levels were assessed by western and ELISA assays. RA administration (10 mg/kg daily) reversed depressive-like behaviors in rats exposed to a chronic unpredictable stress paradigm and restored pERK1/2 protein expression and hippocampal brain-derived neurotrophic factor (BDNF). Moreover, in vitro experiments revealed that 20 μg/mL RA increased pERK1/2 and BDNF levels in cultured astrocytes. Interestingly, the effects of RA were inhibited by U0126. RA might be a useful treatment for depression and the changes in ERK1/2 signaling and BDNF levels may play a critical role in the pharmacological action of RA.
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