Evidence map›Paper›PMID 23756586›Full record

Trial reportJournal of the American College of Nutrition2012

Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial.

David L Katz, Anna Davidhi, Yingying Ma, Yasemin Kavak, Lauren Bifulco, Valentine Yanchou Njike

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American College of Nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03224533 completednot on this mapstarted 2015, after this paper: background citation

Association Between Walnut Consumption and Diabetes Risk in NHANES May be Gender Sex Specific

TypeobservationalSponsorUniversity of California, Los AngelesRan2015 to 2017Enrolled34,121ConditionsDiabetes MellitusArmsDiabetes Outcome
NCT04025281 nacompletednot on this mapstarted 2019, after this paper: background citation

Post-prandial Effects of Extra Virgin Olive Oil on Endothelial Function in Adults at Risk for Type 2 Diabetes: A Randomized Crossover Controlled Trial

TypeinterventionalSponsorGriffin HospitalRan2019 to 2019Enrolled20ConditionsType 2 DiabetesArmsExtra Virgin Olive Oil, Refined Olive Oil
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 18 syntheses or guidelines pooled it.

  1. Effects of Walnut (Juglans regia L.) on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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  17. Nut consumption for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2015
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David L KatzYale University, Griffin Prevention Research Center, 130 Division Street, Derby, CT 06418, USA. katzdl@pol.net
Anna Davidhi
Yingying Ma
Yasemin Kavak
Lauren Bifulco
Valentine Yanchou Njike

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMetabolic syndrome is a precursor of diabetes and cardiovascular disease (CVD). Walnut ingestion has been shown to reduce CVD risk indices in diabetes. This randomized controlled crossover trial was performed to investigate the effects of daily walnut consumption on endothelial function and other biomarkers of cardiac risk in a population of overweight individuals with visceral adiposity.

methodsForty-six overweight adults (average age, 57.4 years; 28 women, 18 men) with elevated waist circumference and 1 or more additional signs of metabolic syndrome were randomly assigned to two 8-week sequences of walnut-enriched ad libitum diet and ad libitum diet without walnuts, which were separated by a 4-week washout period. The primary outcome measure was the change in flow-mediated vasodilation (FMD) of the brachial artery. Secondary measures included serum lipid panel, fasting glucose and insulin, Homeostasis Model Assessment-Insulin Resistance values, blood pressure, and anthropometric measures.

resultsFMD improved significantly from baseline when subjects consumed a walnut-enriched diet as compared with the control diet (1.4% ± 2.4% versus 0.3% ± 1.5%; p = 0.019). Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed. Other measures were unaltered.

conclusionDaily ingestion of 56 g of walnuts improves endothelial function in overweight adults with visceral adiposity. The addition of walnuts to the diet does not lead to weight gain. Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted.

Indexed as

JuglansNutsAdiposityAdultAgedBlood GlucoseBrachial ArteryCardiovascular DiseasesCross-Over StudiesDietary FatsEndothelium, VascularFemaleHumansInsulinMaleMetabolic SyndromeBlood GlucoseDietary FatsInsulinendothelial functionmetabolic syndromewalnut

Identifiers

PMID23756586
PMCPMC3756625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.