ArticleTranslational psychiatry2013
Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- What do DNA methylation studies tell us about depression? A systematic review.Translational psychiatry · 2019Pooled it
- DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.JAMA psychiatry · 2018Pooled it
- Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression.Clinical epigenetics · 2023Article
- DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?Current neuropharmacology · 2022Review
- DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses.Genome medicine · 2022Article
- Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study.Translational psychiatry · 2021Article
- Origins of human disease: the chrono-epigenetic perspective.Nature reviews. Genetics · 2021Review
- Distinct epigenetic signatures between adult-onset and late-onset depression.Scientific reports · 2021Article
- The neuroendocrine modulation of global DNA methylation in neuropsychiatric disorders.Molecular psychiatry · 2021Review
- Novel candidate genes for ECT response prediction-a pilot study analyzing the DNA methylome of depressed patients receiving electroconvulsive therapy.Clinical epigenetics · 2020Article
- DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression.Clinical epigenetics · 2019Article
- Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.Translational psychiatry · 2019Article
- Epigenetics and Depression: An Update.Psychiatry investigation · 2019Article
- Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression.Scientific reports · 2019Article
- Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease.Genome biology · 2019Article
- Study Design and Rationale for the Mood and Methylation Study: A Platform for Multi-Omics Investigation of Depression in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018Article
- Childhood Trauma, DNA Methylation of Stress-Related Genes, and Depression: Findings From Two Monozygotic Twin Studies.Psychosomatic medicine · 2018Observational
- Epigenetic variability in conversion to psychosis: novel findings from an innovative longitudinal methylomic analysis.Translational psychiatry · 2018Article
- An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.Journal of human genetics · 2018Article
- Exact testing with random permutations.Test (Madrid, Spain) · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms influencing susceptibility for complex traits. DNA sequence within discordant monozygotic twin (MZT) pairs is virtually identical; thus, they represent a powerful design for studying the contribution of epigenetic factors to disease liability. The aim of this study was to investigate whether specific methylation profiles in white blood cells could contribute to the aetiology of MDD. Participants were drawn from the Queensland Twin Registry and comprised 12 MZT pairs discordant for MDD and 12 MZT pairs concordant for no MDD and low neuroticism. Bisulphite treatment and genome-wide interrogation of differentially methylated CpG sites using the Illumina Human Methylation 450 BeadChip were performed in WBC-derived DNA. No overall difference in mean global methylation between cases and their unaffected co-twins was found; however, the differences in females was significant (P=0.005). The difference in variance across all probes between affected and unaffected twins was highly significant (P<2.2 × 10⁻¹⁶), with 52.4% of probes having higher variance in cases (binomial P-value<2.2 × 10⁻¹⁶). No significant differences in methylation were observed between discordant MZT pairs and their matched concordant MZT (permutation minimum P=0.11) at any individual probe. Larger samples are likely to be needed to identify true associations between methylation differences at specific CpG sites.
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