ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2013
A targeted review of the neurobiology and genetics of behavioural addictions: an emerging area of research.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 224 citations in OpenAlex.
- Relationships among impulsive, addictive and sexual tendencies and behaviours: a systematic review of experimental and prospective studies in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Pooled it
- Possible relationship between genetic polymorphisms and the risk of exercise addiction among Turkish elite athletes: an exploratory pilot study.Scientific reports · 2026Article
- Addiction to Cosmetic Procedures: A Scoping Literature Review.Aesthetic plastic surgery · 2025Article
- Associations Between Taq1A/C957T Polymorphic Variants and Autonomic Responsivity in a Slot Machine Task: Influence of Real-Life Gambling Exposure and Sex.Journal of gambling studies · 2025Article
- Interplay of cultural beliefs, psychological disposition, and social milieu during childhood on development of substance use disorder by early adulthood.Experimental and clinical psychopharmacology · 2025Article
- Psychometric properties of the Reward Deficiency Syndrome Questionnaire among a non-clinical sample and its relationship with the characteristics of potentially addictive behaviors.Addictive behaviors reports · 2025Article
- Single video games improve cognitive functioning in college students: evidence from behavioral and fNIRS assessments.Frontiers in psychiatry · 2025Article
- Exercise, addiction and motivation: the development of a motivation scale in extreme sports as a sport of challenge with nature.Frontiers in psychology · 2025Article
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Article
- Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction.Frontiers in psychiatry · 2024Review
- Endogenous and Exogenous Opioids: Role in Substance Use Disorders.Advances in neurobiology · 2024Review
- Technology and addiction: What drugs can teach us about digital media.Transcultural psychiatry · 2023Article
- Are there clinical, psychopathological and therapy outcomes correlates associated with self-exclusion from gambling?Journal of behavioral addictions · 2023Article
- Biopsychosocial factors of gaming disorder: a systematic review employing screening tools with well-defined psychometric properties.Frontiers in psychiatry · 2023Review
- The World Federation of Societies of Biological Psychiatry guidelines on the assessment and pharmacological treatment of compulsive sexual behaviour disorder.Dialogues in clinical neuroscience · 2022Article
- Negative urgency moderates the association between compulsive sexual behaviors and sending unsolicited sexts among men in residential treatment for substance use disorders.Computers in human behavior · 2022Article
- Gaming Disorder in Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- The role of neurotrophin genes involved in the vulnerability to gambling disorder.Scientific reports · 2022Article
- FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.Journal of personalized medicine · 2022Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review summarizes neurobiological and genetic findings in behavioural addictions, draws parallels with findings pertaining to substance use disorders, and offers suggestions for future research. Articles concerning brain function, neurotransmitter activity, and family history and (or) genetic findings for behavioural addictions involving gambling, Internet use, video game playing, shopping, kleptomania, and sexual activity were reviewed. Behavioural addictions involve dysfunction in several brain regions, particularly the frontal cortex and striatum. Findings from imaging studies incorporating cognitive tasks have arguably been more consistent than cue-induction studies. Early results suggest white and grey matter differences. Neurochemical findings suggest roles for dopaminergic and serotonergic systems, but results from clinical trials seem more equivocal. While limited, family history and genetic data support heritability for pathological gambling and that people with behavioural addictions are more likely to have a close family member with some form of psychopathology. Parallels exist between neurobiological and genetic and family history findings in substance and nonsubstance addictions, suggesting that compulsive engagement in these behaviours may constitute addictions. To date, findings are limited, particularly for shopping, kleptomania, and sexual behaviour. Genetic understandings are at an early stage. Future research directions are offered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.