ArticleBehavioural brain research2013
Age of exposure-dependent effects of amphetamine on behavioral flexibility.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines.Advances in pharmacology (San Diego, Calif.) · 2024Article
- CXCR4 inhibition with AMD3100 attenuates amphetamine induced locomotor activity in adolescent Long Evans male rats.PloS one · 2021Article
- AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.Pharmacology, biochemistry, and behavior · 2020Review
- Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats.Behavioural brain research · 2020Article
- DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence.Addiction biology · 2020Article
- D-Amphetamine Exposure Differentially Disrupts Signaling Across Ontogeny in the Zebrafish.Bioelectricity · 2019Article
- d-Amphetamine and methylmercury exposure during adolescence alters sensitivity to monoamine uptake inhibitors in adult mice.Neurotoxicology · 2019Article
- Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HTBehavioural brain research · 2018Article
- Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood.Brain research · 2018Article
- Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Effects of adolescent exposure to methylmercury and d-amphetamine on reversal learning and an extradimensional shift in male mice.Experimental and clinical psychopharmacology · 2017Article
- Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine DNeuroscience · 2016Article
- Repeated exposure to amphetamine during adolescence alters inhibitory tone in the medial prefrontal cortex following drug re-exposure in adulthood.Behavioural brain research · 2016Article
- D1 receptor-mediated inhibition of medial prefrontal cortex neurons is disrupted in adult rats exposed to amphetamine in adolescence.Neuroscience · 2016Article
- Sex differences in behavior and neural development and their role in adolescent vulnerability to substance use.Behavioural brain research · 2016Review
- Adolescent D-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood.Behavioural brain research · 2016Article
- Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure.Psychopharmacology · 2014Article
- Effects of amphetamine exposure in adolescence or young adulthood on inhibitory control in adult male and female rats.Behavioural brain research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Drug use typically begins during adolescence, which is a period of ongoing neurobiological development that may confer heightened vulnerability to develop drug dependence. Previously, our lab has shown that amphetamine (AMPH)-induced deficits in a medial prefrontal cortex (mPFC)-sensitive working memory task are greater in rats exposed to the drug during adolescence compared to adulthood. Here, we examine potential age-dependent effects of AMPH exposure on behavioral flexibility tasks that are sensitive to disruptions in mPFC and orbitofrontal cortex (OFC) function. Male Sprague-Dawley rats were injected (i.p.) with saline or 3mg/kg AMPH every other day between postnatal days (PNDs) 27-45 and PNDs 85-103. Starting around PND 125, rats were tested in an attentional set-shifting task and a subset of those was then tested in an operant strategy shifting task. Following completion of the operant task, rats were challenged with 3mg/kg AMPH and monitored in open field chambers. Our results demonstrate that AMPH-exposed rats were faster to acquire simple and compound discriminations, but were impaired during the first stimulus-reward reversal when compared to controls. In the operant strategy shifting task, adolescent-exposed rats shifted more rapidly between strategies and completed reversals faster than adult-exposed and control rats, respectively. The final AMPH challenge revealed evidence for sensitization in drug pre-exposed rats, with adult-exposed animals exhibiting the most significant effects. Together, these results suggest that AMPH induces long-lasting changes in behavioral flexibility that are at least partially dependent on age of exposure and may be due to adaptations in OFC function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.