ArticleExperimental cell research2013
Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation.
Article in Experimental cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026Review
- Gene expression alterations in hypoxic A549 lung cancer cell line.Biomedical reports · 2024Article
- International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.Pharmacological reviews · 2023Review
- Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors.Science advances · 2023Article
- Article
- Adapting Physiology in Functional Human Islet Organogenesis.Frontiers in cell and developmental biology · 2022Article
- Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.Communications biology · 2021Article
- The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field.Frontiers in nutrition · 2021Review
- Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects.Frontiers in endocrinology · 2021Review
- Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.The Journal of biological chemistry · 2018Article
- Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis.The Journal of nutritional biochemistry · 2018Article
- A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Upregulation of retinoic acid receptor-β reverses drug resistance in cholangiocarcinoma cells by enhancing susceptibility to apoptosis.Molecular medicine reports · 2016Article
- Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis.Diabetes, obesity & metabolism · 2016Article
- Retinoids in the pancreas.Hepatobiliary surgery and nutrition · 2016Review
- RARβ regulates neuronal cell death and differentiation in the avian ciliary ganglion.Developmental neurobiology · 2015Article
- Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion.Current diabetes reports · 2015Review
- In vitro differentiation of human umbilical cord Wharton's jelly mesenchymal stromal cells to insulin producing clusters.World journal of clinical cases · 2015Article
- Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.The Journal of biological chemistry · 2015Article
- Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
All-trans retinoic acid (RA) signals via binding to retinoic acid receptors (RARs α, β, and γ). RA directly influences expression of Pdx1, a transcription factor essential for pancreatic development and beta-cell (β-cell) maturation. In this study we follow the differentiation of cultured wild-type (WT) vs. RARβ knockout (KO) embryonic stem (ES) cells into pancreatic islet cells. We found that RARβ KO ES cells show greatly reduced expression of some important endocrine markers of differentiated islet cells, such as glucagon, islet amyloid polypeptide (Iapp), and insulin 1 (Ins1) relative to WT. We conclude that RARβ activity is essential for proper differentiation of ES cells to pancreatic endocrine cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.