ArticleAIDS care2014
The impact of neurobehavioral features on medication adherence in HIV: evidence from longitudinal models.
Article in AIDS care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The Association of Apathy With Incident Dementia: A Multiple Mediation Analysis of Cardiovascular Risk Factors.International journal of geriatric psychiatry · 2025Article
- Does Social Support Play a Role in the Expression and Everyday Functioning Impact of Apathy in HIV Disease?AIDS and behavior · 2024Article
- Motivation levels and white matter microstructure in children living with HIV.Scientific reports · 2024Article
- Microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of HIV-1-associated neurocognitive and affective alterations.Journal of neurovirology · 2023Article
- HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits.Cells · 2021Review
- Apathy is Associated with Critical Psychological Determinants of Medication Adherence in HIV Disease.Journal of clinical psychology in medical settings · 2021Article
- Cognitive Training: Associations and Implications for Weight Management and Translational Research.Translational journal of the American College of Sports Medicine · 2021Article
- Mental Health and Functional Competence in the Cape Town Adolescent Antiretroviral Cohort.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat.Frontiers in behavioral neuroscience · 2018Article
- Cannabis Use, Medication Management and Adherence Among Persons Living with HIV.AIDS and behavior · 2017Article
- High early life stress and aberrant amygdala activity: risk factors for elevated neuropsychiatric symptoms in HIV+ adults.Brain imaging and behavior · 2017Article
- Development and Validation of the Parkinson's Disease Medication Beliefs Scale (PD-Rx).Journal of Parkinson's disease · 2016Article
- Neurobehavioral Manifestations of Human Immunodeficiency Virus/AIDS: Diagnosis and Treatment.Neurologic clinics · 2016Review
- A Bidirectional Relationship between Executive Function and Health Behavior: Evidence, Implications, and Future Directions.Frontiers in neuroscience · 2016Review
- Psychosocial Correlates of Medication Adherence among HIV-Positive, Cognitively Impaired Individuals.Journal of HIV/AIDS & social services · 2016Article
- True durability: HIV virologic suppression in an urban clinic and implications for timing of intensive adherence efforts and viral load monitoring.AIDS and behavior · 2015Article
- Interactive effects of neurocognitive impairment and substance use on antiretroviral non-adherence in HIV disease.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2015Article
- HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.Frontiers in microbiology · 2015Article
- Association between functional performance and executive cognitive functions in an elderly population including patients with low ankle-brachial index.Clinical interventions in aging · 2015Article
- Host genetic factors predisposing to HIV-associated neurocognitive disorder.Current HIV/AIDS reports · 2014Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Effective antiretroviral therapy has led to substantial improvements in health-related outcomes among individuals with HIV. Despite advances in HIV pharmacotherapy, suboptimal medication adherence remains a significant barrier to successful treatment. Although several factors have been associated with medication adherence in the extant literature, study assessing the effects of some of the neurobehavioral features specific to HIV has been limited. Moreover, although there is a growing body of literature measuring medication adherence in HIV prospectively, few employ advanced statistical methodologies suited to handle advanced models with multiple predictors that would strengthen our understanding of medication adherence trajectories in HIV. This study sought to integrate traditionally assessed predictors of medication adherence with neurobehavioral features of HIV in a longitudinal study of medication adherence to combined antiretroviral therapy (cART). The current study used multilevel modeling to examine a wide arrangement of categories of factors - demographic, medication related, psychosocial, and neurobehavioral - on medication adherence. The sample consisted of 235 HIV+ individuals whose medication adherence was monitored over the course of six months using electronic monitoring devices. After controlling for the effects of demographic, medication, and psychosocial factors, neurobehavioral features added predictive validity to the model. In the final model, simultaneously controlling for the effects of each of the predictors within all the categories, age, self-efficacy, executive functioning, apathy, and frequency of stimulant use emerged as unique individual predictors of average medication adherence across the 6-month study. Self-efficacy and irritability predicted changes in medication adherence over time. Adherence behavior is multidetermined. Adequate assessment of these factors, combined with timely intervention, appears to be warranted in order to boost adherence rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.