ArticleJournal of vascular surgery2013
Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing.
Article in Journal of vascular surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Establishment and translational evaluation of animal models for skin wound healing: a systematic review.Frontiers in physiology · 2026Pooled it
- Remote periosteal distraction promotes ischemic diabetic foot wound repair associated with VEGF/VEGFR2-related angiogenic responses.Journal of molecular histology · 2026Article
- Diabetes and its complications: molecular mechanisms, prevention and treatment.Signal transduction and targeted therapy · 2026Review
- Reversing diabetic wound stagnation: macrophage polarization dysregulation as a therapeutic linchpin from pathogenesis to precision interventions.Burns & trauma · 2026Review
- PVA and PVP nanofibers combined with Helichrysum italicum oil preserve skin cell interactions, elasticity and proliferation.Scientific reports · 2025Article
- Review
- Use of Therapeutic RNAs to Accelerate Wound Healing in Diabetic Rabbit Wounds.Advances in wound care · 2024Article
- Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing.The American journal of case reports · 2024Article
- Topical Neuropeptide Y for Ischemic Skin Wounds.International journal of molecular sciences · 2024Article
- Assessment of wound healing activity in diabetic mice treated with a novel therapeutic combination of selenium nanoparticles and platelets rich plasma.Scientific reports · 2024Article
- Preparation of therapy-grade extracellular vesicles from adipose tissue to promote diabetic wound healing.Frontiers in bioengineering and biotechnology · 2023Article
- Review
- Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice.Biomaterials · 2022Article
- DPSC Products Accelerate Wound Healing in Diabetic Mice through Induction of SMAD Molecules.Cells · 2022Article
- IL-1B can serve as a healing process and is a critical regulator of diabetic foot ulcer.Annals of translational medicine · 2022Article
- Topical gel-based biomaterials for the treatment of diabetic foot ulcers.Acta biomaterialia · 2022Review
- Cutaneous innervation in impaired diabetic wound healing.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Changes in digestive enzyme activities during the early ontogeny of the South American cichlid (Cichlasoma dimerus).Fish physiology and biochemistry · 2021Article
- A Novel Three-Dimensional Skin Disease Model to Assess Macrophage Function in Diabetes.Tissue engineering. Part C, Methods · 2021Article
- Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications.Frontiers in endocrinology · 2021Review
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveThe present study is designed to understand the contribution of peripheral vascular disease and peripheral neuropathy to the wound-healing impairment associated with diabetes. Using a rabbit model of diabetic neuroischemic wound healing, we investigated rate of healing, leukocyte infiltration, and expression of cytokines, interleukin-8 and interleukin-6, and neuropeptides, substance P, and neuropeptide Y.
methodsDiabetes was induced in New Zealand White rabbits by administering alloxan while control rabbits received saline. Ten days later, animals in both groups underwent surgery. One ear served as a sham, and the other was made ischemic (ligation of central+rostral arteries) or neuroischemic (ischemia+ resection of central+rostral nerves). Four 6-mm punch biopsy wounds were created in both ears and wound healing was followed for 10 days using computerized planimetry.
resultsNondiabetic sham and ischemic wounds healed significantly more rapidly than diabetic sham and ischemic wounds. Healing was slowest in neuroischemic wounds, irrespective of diabetic status. A high M1/M2 macrophage ratio and a high proinflammatory cytokine expression, both indicators of chronic proinflammatory state, and low neuropeptide expression were seen in preinjury diabetic skin. Postinjury, in diabetic wounds, the M1/M2 ratio remained high, the reactive increase in cytokine expression was low, and neuropeptide expression was further decreased in neuroischemic wounds.
conclusionsThis rabbit model illustrates how a combination of a high M1/M2 ratio, a failure to mount postinjury cytokine response as well as a diminished neuropeptide expression, contribute to wound-healing impairment in diabetes. The addition of neuropathy to ischemia leads to equivalently severe impaired wound-healing irrespective of diabetes status, suggesting that in the presence of ischemia, loss of neuropeptide function contributes to the impaired healing associated with diabetes.
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