ArticleFertility and sterility2013
Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women's Health Across the Nation.
Article in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 86 citations in OpenAlex.
- A prospective, randomized, double-blind, placebo-controlled study on efficacy and safety of Ashwagandha root extract (Frontiers in reproductive health · 2025Trial
- Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report.Menopause (New York, N.Y.) · 2018Trial
- Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women.Menopause (New York, N.Y.) · 2017Trial
- Behavioral weight loss for the management of menopausal hot flashes: a pilot study.Menopause (New York, N.Y.) · 2015Trial
- Blood proteomics of menopause map to brain aging and dementia risk.Nature medicine · 2026Article
- Body roundness index and a body shape index and their associations with menopausal symptoms: a comparative cross-sectional study.BMC women's health · 2026Article
- Adverse Cardiometabolic Impacts of Sleep Fragmentation and Estradiol Suppression: An Experimental Model of Menopause.The Journal of clinical endocrinology and metabolism · 2026Article
- Effects of menopause on temperature regulation.Temperature (Austin, Tex.) · 2025Review
- Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross-sectional and cohort studies.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- The interplay between diabetes mellitus and menopause: clinical implications.Nature reviews. Endocrinology · 2022Review
- Nonalcoholic Fatty Liver Disease and Risk of Early-Onset Vasomotor Symptoms in Lean and Overweight Premenopausal Women.Nutrients · 2022Article
- Nutritional Risk Factors Associated with Vasomotor Symptoms in Women Aged 40-65 Years.Nutrients · 2022Article
- Individual Characteristics Associated with Menopausal Symptom Severity and Menopause-Specific Quality of Life: A Rural Perspective.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Vasomotor Symptoms: More Than Temporary Menopausal Symptoms.Journal of menopausal medicine · 2020Review
- Perimenopause, body fat, metabolism and menopausal symptoms in relation to serum markers of adiposity, inflammation and digestive metabolism.Journal of endocrinological investigation · 2020Article
- Association of hot flushes with ghrelin and adipokines in early versus late postmenopausal women.Menopause (New York, N.Y.) · 2020Article
- Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women's Health Initiative (WHI).The Journal of clinical endocrinology and metabolism · 2020 · on this mapObservational
- Association of lean body mass to menopausal symptoms: The Study of Women's Health Across the Nation.Women's midlife health · 2020Article
- Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases.Molecules (Basel, Switzerland) · 2019Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo test relationships between adipokines, adiposity, and vasomotor symptoms (VMS), including how these associations vary by menopause stage.
designA subcohort of the longitudinal cohort Study of Women's Health Across the Nation completed questionnaires, physical measures, and a fasting blood draw annually for 8 years. Associations between a poorer adipokine profile (lower adiponectin, lower high-molecular-weight [HMW] adiponectin, higher leptin, lower soluble leptin receptor, higher monocyte chemoattractant protein 1 [MCP-1]) and VMS were tested with the use of generalized estimating equations adjusting for potential confounders. Interactions by menopause stage (pre-/early perimenopause, late peri-/postmenopause) were tested.
settingCommunity. PATIENT(S): A total of 536 women ages 42-52 at baseline. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S) VMS RESULT(S): Associations between adipokines and hot flashes varied by menopause stage, with a poorer adipokine profile associated with higher odds of hot flashes early in the transition (adiponectin(log): odds ratio [OR] 0.68, 95% confidence interval [CI] 0.51-0.90; HMW adiponectin(log): OR 0.70, 95% CI 0.58-0.85; leptin(log): OR 1.23, 95% CI 0.99-1.54; multivariable models including body mass index [BMI]), but not later in the transition. The direction of associations between BMI and VMS also varied by menopausal stage. Higher MCP-1 was associated with more night sweats (OR 1.37, 95% CI 1.06-1.76) across menopausal stages. CONCLUSION(S): An adverse adipokine profile was associated with more VMS, particularly early in the menopause transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.