ArticlePLoS neglected tropical diseases2013
Schistosoma japonicum soluble egg antigens attenuate invasion in a first trimester human placental trophoblast model.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The underestimated burden of placental schistosomiasis in endemic regions: Findings from a cross-sectional, diagnostic proof-of-concept study on placental schistosomiasis in Gabon.PLoS neglected tropical diseases · 2026Article
- Schistosomiasis: a neglected cause of infertility in females and males.Current opinion in infectious diseases · 2025Review
- Improvement of a tissue maceration technique for the determination of placental involvement in schistosomiasis.PLoS neglected tropical diseases · 2017Article
- An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs.PLoS neglected tropical diseases · 2015Article
- Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease.American journal of respiratory and critical care medicine · 2015Article
- Schistosoma mansoni soluble egg antigens enhance Listeria monocytogenes vector HIV-1 vaccine induction of cytotoxic T cells.Clinical and vaccine immunology : CVI · 2014Article
- Pregnancy and helminth infections.Parasite immunology · 2014Review
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSchistosomiasis affects nearly 40 million women of reproductive age, and is known to elicit a pro-inflammatory signature in the placenta. We have previously shown that antigens from schistosome eggs can elicit pro-inflammatory cytokine production from trophoblast cells specifically; however, the influence of these antigens on other characteristics of trophoblast function, particularly as it pertains to placentation in early gestation, is unknown. We therefore sought to determine the impact of schistosome antigens on key characteristics of first trimester trophoblast cells, including migration and invasion.
methodsFirst trimester HTR8/SVneo trophoblast cells were co-cultured with plasma from pregnant women with and without schistosomiasis or schistosome soluble egg antigens (SEA) and measured cytokine, cellular migration, and invasion responses.
resultsExposure of HTR8 cells to SEA resulted in a pro-inflammatory, anti-invasive signature, characterized by increased pro-inflammatory cytokines (IL-6, IL-8, MCP-1) and TIMP-1. Additionally, these cells displayed 62% decreased migration and 2.7-fold decreased invasion in vitro after treatment with SEA. These results are supported by increased IL-6 and IL-8 in the culture media of HTR8 cells exposed to plasma from Schistosoma japonica infected pregnant women.
conclusionsSoluble egg antigens found in circulation during schistosome infection increase pro-inflammatory cytokine production and inhibit the mobility and invasive characteristics of the first trimester HTR8/SVneo trophoblast cell line. This is the first study to assess the impact of schistosome soluble egg antigens on the behavior of an extravillous trophoblast model and suggests that schistosomiasis in the pre-pregnancy period may adversely impact placentation and the subsequent health of the mother and newborn.
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