ArticlePloS one2013
Complete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Whole-genome sequencing and analysis of Nocardia veterana isolates from keratitis patients.Molecular genetics and genomics : MGG · 2026Article
- Phylogenetic and Genomic Feature Analysis of CutaneousInfection and drug resistance · 2026Article
- Molecular mechanisms underlyingFrontiers in cellular and infection microbiology · 2026Review
- Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.Annals of clinical microbiology and antimicrobials · 2025Article
- Effect of β - hydroxy - γ -aminophosphonate (β - HPC) on the hydrolytic activity ofFrontiers in microbiology · 2023Article
- Updated Review onClinical microbiology reviews · 2022Review
- Identification of Differentially Expressed Genes in Nocardia brasiliensis Induced by Progesterone and Dihydrotestosterone Using Differential Display PCR.Current microbiology · 2022Article
- Comparative genomics ofMicrobial genomics · 2022Article
- A Complete Genome ofInfection and drug resistance · 2022Article
- Comparison of carbohydrate ABC importers from Mycobacterium tuberculosis.BMC genomics · 2021Article
- Insights from the comparative genome analysis of natural rubber degradingBioinformation · 2021Article
- Genomic Virulence Features of Two Novel SpeciesMicroorganisms · 2020Article
- New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.Chembiochem : a European journal of chemical biology · 2020Article
- Screening and Identification of B-Cell Epitopes in the P61 Protein ofFrontiers in cellular and infection microbiology · 2018Article
- Non-Coding RNAs are Differentially Expressed byThe open microbiology journal · 2017Article
- Article
- Cloning, Expression, Invasion, and Immunological Reactivity of a Mammalian Cell Entry Protein Encoded by the mce1 Operon ofFrontiers in microbiology · 2017Article
- Article
- Genomic Changes Associated with the Loss of Nocardia brasiliensis Virulence in Mice after 200 In Vitro Passages.Infection and immunity · 2016Article
- Genome Sequence of Madurella mycetomatis mm55, Isolated from a Human Mycetoma Case in Sudan.Genome announcements · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nocardia brasiliensis is an important etiologic agent of mycetoma. These bacteria live as a saprobe in soil or organic material and enter the tissue via minor trauma. Mycetoma is characterized by tumefaction and the production of fistula and abscesses, with no spontaneous cure. By using mass sequencing, we determined the complete genomic nucleotide sequence of the bacteria. According to our data, the genome is a circular chromosome 9,436,348-bp long with 68% G+C content that encodes 8,414 proteins. We observed orthologs for virulence factors, a higher number of genes involved in lipid biosynthesis and catabolism, and gene clusters for the synthesis of bioactive compounds, such as antibiotics, terpenes, and polyketides. An in silico analysis of the sequence supports the conclusion that the bacteria acquired diverse genes by horizontal transfer from other soil bacteria, even from eukaryotic organisms. The genome composition reflects the evolution of bacteria via the acquisition of a large amount of DNA, which allows it to survive in new ecological niches, including humans.
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