ArticlePloS one2013
Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 394 citations in OpenAlex.
- Mechanistic Basis of Nanobubble Functionality in Food Systems: Linking Electrokinetic Stabilization, Transport Dynamics, and Functional Outcomes.Comprehensive reviews in food science and food safety · 2026Review
- Stable charged nanobubbles with distinct polarities in culture media differentially affect the viability of human iPSC-derived neurons.Scientific reports · 2026Article
- Utilizing Carbonated Reclaimed Water as Concrete Mixing Water: Improved COMaterials (Basel, Switzerland) · 2025Article
- Ultrafine bubble water irrigation promotes soil particle fragmentation and reduces soil hardness in paddy fields.Scientific reports · 2025Article
- Ozone Nanobubble Water as a Sustainable Strategy to Enhance Metabolism, Muscle Function, and Exercise Performance in Mice.Nutrients · 2025Article
- Properties of CONanomaterials (Basel, Switzerland) · 2025Review
- Integrated Microbiome, Transcriptome, and Physiology Analyses Reveal the Response Of Kuruma Shrimp (Penaeus japonicus) to Oxygen Nanobubble Exposure.Marine biotechnology (New York, N.Y.) · 2025Article
- Article
- Nanobubble nucleation by pulsed laser illumination of colloidal gold nanoparticles.Scientific reports · 2024Article
- Increased Absorption of Thyroxine in a Murine Model of Hypothyroidism Using Water/COInternational journal of molecular sciences · 2024Article
- Investigating the effects of ultrafine bubbles on bacterial growth.RSC advances · 2024Article
- Nanobubbles in vase water inhibit transpiration and prolong the vase life of cut chrysanthemum flowers.Plant-environment interactions (Hoboken, N.J.) · 2023Article
- The effects of exposure to OScientific reports · 2023Article
- NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies.Nanomaterials (Basel, Switzerland) · 2023Review
- Effect of chemical species and temperature on the stability of air nanobubbles.Scientific reports · 2023Article
- The Effect of Nanobubbles on Transdermal Applications.Nanomaterials (Basel, Switzerland) · 2023Article
- Promotion Effects of Ultrafine Bubbles/Nanobubbles on Seed Germination.Nanomaterials (Basel, Switzerland) · 2023Article
- Accelerated germination of aged recalcitrant seeds by KScientific reports · 2023Article
- Characterization of Oxygen Nanobubbles and In Vitro Evaluation of Retinal Cells in Hypoxia.Translational vision science & technology · 2023Article
- Capacity ofPlants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanobubbles (<200 nm in diameter) have several unique properties such as long lifetime in liquid owing to its negatively charged surface, and its high gas solubility into the liquid owing to its high internal pressure. They are used in variety of fields including diagnostic aids and drug delivery, while there are no reports assessing their effects on the growth of lives. Nanobubbles of air or oxygen gas were generated using a nanobubble aerator (BUVITAS; Ligaric Company Limited, Osaka, Japan). Brassica campestris were cultured hydroponically for 4 weeks within air-nanobubble water or within normal water. Sweetfish (for 3 weeks) and rainbow trout (for 6 weeks) were kept either within air-nanobubble water or within normal water. Finally, 5 week-old male DBA1/J mice were bred with normal free-chaw and free-drinking either of oxygen-nanobubble water or of normal water for 12 weeks. Oxygen-nanobubble significantly increased the dissolved oxygen concentration of water as well as concentration/size of nanobubbles which were relatively stable for 70 days. Air-nanobubble water significantly promoted the height (19.1 vs. 16.7 cm; P<0.05), length of leaves (24.4 vs. 22.4 cm; P<0.01), and aerial fresh weight (27.3 vs. 20.3 g; P<0.01) of Brassica campestris compared to normal water. Total weight of sweetfish increased from 3.0 to 6.4 kg in normal water, whereas it increased from 3.0 to 10.2 kg in air-nanobubble water. In addition, total weight of rainbow trout increased from 50.0 to 129.5 kg in normal water, whereas it increased from 50.0 to 148.0 kg in air-nanobubble water. Free oral intake of oxygen-nanobubble water significantly promoted the weight (23.5 vs. 21.8 g; P<0.01) and the length (17.0 vs. 16.1 cm; P<0.001) of mice compared to that of normal water. We have demonstrated for the first time that oxygen and air-nanobubble water may be potentially effective tools for the growth of lives.
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