ArticlePloS one2013
Evolutionary relationship and structural characterization of the EPF/EPFL gene family.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
- Comprehensive Profiling of the RicePlants (Basel, Switzerland) · 2026Article
- Small Signaling Peptides inPlant direct · 2026Article
- Pan-genomic diversity of the EPF/EPFL gene family across wild and modern wheat species.BMC plant biology · 2026Article
- From roots to reproduction: the multifaceted roles of rapid alkalinization factor and epidermal patterning factor peptides in plants.Journal of experimental botany · 2025Review
- An updated history of TDIF-PXY signalling: a study in cell fate and tissue patterning.The New phytologist · 2025Review
- The peptide EPFL8 represses embryonic stomatal precursor formation independently of TOO MANY MOUTHS in Arabidopsis.Plant physiology · 2025Article
- Advances of Peptides for Plant Immunity.Plants (Basel, Switzerland) · 2025Review
- Genetic analysis of the single internode dwarf 1 mutant in barley.BMC plant biology · 2025Article
- Comprehensive genome-wide identification and expression analysis of the EPF/EPFL gene family in oat.BMC genomics · 2025Article
- Peptide hormones in plants.Molecular horticulture · 2025Review
- How parental factors shape the plant embryo.Biochemical Society transactions · 2025Article
- Comparative Genomics Analysis of the Populus Epidermal Pattern Factor (EPF) Family Revealed Their Regulatory Effects inInternational journal of molecular sciences · 2024Article
- Article
- Investigation on the Potential Functions of ZmEPF/EPFL Family Members in Response to Abiotic Stress in Maize.International journal of molecular sciences · 2024Article
- An updated model of shoot apical meristem regulation by ERECTA family and CLAVATA3 signaling pathways in Arabidopsis.Development (Cambridge, England) · 2024Article
- Genome-wide analyses of member identification, expression pattern, and protein-protein interaction of EPF/EPFL gene family in Gossypium.BMC plant biology · 2024Article
- Genome-wide identification and phylogenetic and expression pattern analyses of EPF/EPFL family genes in the Rye (Secale cereale L.).BMC genomics · 2024Article
- Genome-wide identification and expression analysis ofFrontiers in genetics · 2024Article
- Redefining awn development in rice through the breeding history of Japanese awn reduction.Frontiers in plant science · 2024Article
- Genome-Wide Identification and Analysis of the EPF Gene Family inPlants (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EPF1-EPF2 and EPFL9/Stomagen act antagonistically in regulating leaf stomatal density. The aim of this study was to elucidate the evolutionary functional divergence of EPF/EPFL family genes. Phylogenetic analyses showed that AtEPFL9/Stomagen-like genes are conserved only in vascular plants and are closely related to AtEPF1/EPF2-like genes. Modeling showed that EPF/EPFL peptides share a common 3D structure that is constituted of a scaffold and loop. Molecular dynamics simulation suggested that AtEPF1/EPF2-like peptides form an additional disulfide bond in their loop regions and show greater flexibility in these regions than AtEPFL9/Stomagen-like peptides. This study uncovered the evolutionary relationship and the conformational divergence of proteins encoded by the EPF/EPFL family genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.