ArticlePloS one2014
Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Serum resistin as a potential biomarker for stratifying the severity of coronary heart disease: a network meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus.Endocrine · 2016Pooled it
- Association between resistin levels and all-cause and cardiovascular mortality: a new study and a systematic review and meta-analysis.PloS one · 2015Pooled it
- Wild blueberries and cardiometabolic health: a current review of the evidence.Critical reviews in food science and nutrition · 2026Review
- Development and Validation of a Predictive Score for Three-Year Mortality in Acute Ischemic Stroke Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Aging adipose tissue, insulin resistance, and type 2 diabetes.Biogerontology · 2024Review
- Differential prognostic value of resistin for cardiac death in patients with coronary artery disease according to the presence of metabolic syndrome.Heart and vessels · 2022Article
- Roles of plasma leptin and resistin in novel subgroups of type 2 diabetes driven by cluster analysis.Lipids in health and disease · 2022Article
- Resistin and Cardiovascular Disease: A Review of the Current Literature Regarding Clinical and Pathological Relationships.Current cardiology reviews · 2022Review
- Fatty Acid Binding Protein-4 and Risk of Cardiovascular Disease: The Cardiovascular Health Study.Journal of the American Heart Association · 2020Observational
- Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus.The Journal of international medical research · 2020Article
- Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation.Scientific reports · 2019Article
- Oxidative stress and adipokine levels were significantly correlated in diabetic patients with hyperglycemic crises.Diabetology & metabolic syndrome · 2019Article
- Physical activity increases the resistin concentration in hemodialyzed patients without metabolic syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- The Anti-Inflammatory Effects of Testosterone.Journal of the Endocrine Society · 2019Review
- Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study.Cardiovascular diabetology · 2018Article
- Association between Resistin Gene Polymorphisms and Atopic Dermatitis.Biomolecules · 2018Article
- Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection.Oncotarget · 2017Article
- Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice.Neurochemical research · 2017Article
- PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages.Atherosclerosis · 2017Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundHigh serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes.
methodsWe tested the association of circulating resistin concentrations with coronary artery disease, major cardiovascular events (cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) and all-cause mortality in 2,313 diabetic patients of European ancestry from two cross-sectional and two prospective studies. In addition, the expression of resistin gene (RETN) was measured in blood cells of 68 diabetic patients and correlated with their serum resistin levels.
resultsIn a model comprising age, sex, smoking habits, BMI, HbA1c, and insulin, antihypertensive and antidyslipidemic therapies, serum resistin was associated with coronary artery disease in both cross-sectional studies: OR (95%CI) per SD increment = 1.35 (1.10-1.64) and 1.99 (1.55-2.55). Additionally, serum resistin predicted incident major cardiovascular events (HR per SD increment = 1.31; 1.10-1.56) and all-cause mortality (HR per SD increment = 1.16; 1.06-1.26). Adjusting also for fibrinogen levels affected the association with coronary artery disease and incident cardiovascular events, but not that with all cause-mortality. Finally, serum resistin was positively correlated with RETN mRNA expression (rho = 0.343).
conclusionsThis is the first study showing that high serum resistin (a likely consequence, at least partly, of increased RETN expression) is a risk factor for cardiovascular disease and all-cause mortality in diabetic patients of European ancestry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.