ArticleFrontiers in genetics2013
eQTL Epistasis - Challenges and Computational Approaches.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Signatures of Co-evolution and Co-regulation in the CYP3A and CYP4F Genes in Humans.Genome biology and evolution · 2024Article
- Article
- Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.Journal of translational genetics and genomics · 2021Article
- Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions.Stem cell reports · 2020Article
- A parallelized strategy for epistasis analysis based on Empirical Bayesian Elastic Net models.Bioinformatics (Oxford, England) · 2020Article
- Evolutionary footprint of epistasis.PLoS computational biology · 2018Article
- Genome-Wide Expression Quantitative Trait Loci Analysis Using Mixed Models.Frontiers in genetics · 2018Review
- Epistasis analysis of microRNAs on pathological stages in colon cancer based on an Empirical Bayesian Elastic Net method.BMC genomics · 2017Article
- Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.PLoS genetics · 2017Article
- Functional regression method for whole genome eQTL epistasis analysis with sequencing data.BMC genomics · 2017Article
- Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.Molecular psychiatry · 2016Article
- An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data.Genes and immunity · 2016Article
- POEM: Identifying Joint Additive Effects on Regulatory Circuits.Frontiers in genetics · 2016Article
- A survey about methods dedicated to epistasis detection.Frontiers in genetics · 2015Review
- Detecting epistasis in human complex traits.Nature reviews. Genetics · 2014Review
- Regularized machine learning in the genetic prediction of complex traits.PLoS genetics · 2014Article
- Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains.Genetics · 2014Article
- Discovering epistasis in large scale genetic association studies by exploiting graphics cards.Frontiers in genetics · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The determination of expression quantitative trait loci (eQTL) epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step toward the thorough understanding of gene regulation. Since gene expression has emerged as an "intermediate" molecular phenotype eQTL epistasis might help to explain the relationship between genotype and higher level organismal phenotypes such as diseases. A characteristic feature of eQTL analysis is the big number of tests required to identify associations between gene expression and genetic loci variability. This problem is aggravated, when epistatic effects between eQTLs are analyzed. In this review, we discuss recent algorithmic approaches for the detection of eQTL epistasis and highlight lessons that can be learned from current methods.
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