ArticleFrontiers in genetics2012
Bridging the Gap between Genotype and Phenotype via Network Approaches.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Identification and Characterization of sQTLs and eQTLs Associated with Growth Traits in Yellow-Feathered Broilers.Poultry science · 2026Article
- A mathematical framework for the quantitative analysis of genetic buffering.PLoS genetics · 2025Article
- The Role of DGAT1-AluI and CAST-MspI Polymorphisms in Early Growth Traits of Morkaraman Lambs.Veterinary medicine and science · 2025Article
- Identification of Gene Expression and Splicing QTLs in Porcine Muscle Associated with Meat Quality Traits.Animals : an open access journal from MDPI · 2025Article
- Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach.International journal of molecular sciences · 2024Article
- Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View.Genes · 2022Review
- GAL Regulon in the YeastFrontiers in molecular biosciences · 2022Article
- Artificial intelligence, molecular subtyping, biomarkers, and precision oncology.Emerging topics in life sciences · 2021Review
- Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection.eLife · 2021Article
- Grand Challenges for Artificial Intelligence in Molecular Medicine.Frontiers in molecular medicine · 2021Article
- Genome-wide analysis of expression QTL (eQTL) and allele-specific expression (ASE) in pig muscle identifies candidate genes for meat quality traits.Genetics, selection, evolution : GSE · 2020Article
- uKIN Combines New and Prior Information with Guided Network Propagation to Accurately Identify Disease Genes.Cell systems · 2020Article
- Causal phenotypic networks for egg traits in an FMolecular genetics and genomics : MGG · 2019Article
- Encircling the regions of the pharmacogenomic landscape that determine drug response.Genome medicine · 2019Article
- Applications of molecular networks in biomedicine.Biology methods & protocols · 2019Review
- Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls.Journal of molecular biology · 2018Review
- Article
- WeSME: uncovering mutual exclusivity of cancer drivers and beyond.Bioinformatics (Oxford, England) · 2017Article
- RNA sequencing of archived neonatal dried blood spots.Molecular genetics and metabolism reports · 2017Article
- A network-driven approach for genome-wide association mapping.Bioinformatics (Oxford, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last few years we have witnessed tremendous progress in detecting associations between genetic variations and complex traits. While genome-wide association studies have been able to discover genomic regions that may influence many common human diseases, these discoveries created an urgent need for methods that extend the knowledge of genotype-phenotype relationships to the level of the molecular mechanisms behind them. To address this emerging need, computational approaches increasingly utilize a pathway-centric perspective. These new methods often utilize known or predicted interactions between genes and/or gene products. In this review, we survey recently developed network based methods that attempt to bridge the genotype-phenotype gap. We note that although these methods help narrow the gap between genotype and phenotype relationships, these approaches alone cannot provide the precise details of underlying mechanisms and current research is still far from closing the gap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.