ArticleFrontiers in microbiology2013
The antibiotic resistance "mobilome": searching for the link between environment and clinic.
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.
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Who cites it
129 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments.Applied and environmental microbiology · 2023Pooled it
- Predicting resistance evolution to guide antibiotic development.Nature reviews. Microbiology · 2026Review
- Dual-platform metagenomic surveillance distinguishes pathogen and resistome hotspots across agricultural and mixed-use watersheds.One health (Amsterdam, Netherlands) · 2026Article
- Elevated COToxics · 2026Article
- Ornithinibacillus liuyingii sp. nov.: a novel multidrug-resistant and potentially pathogenic bacterium isolated from Apodemus chevrieri lung tissue.BMC microbiology · 2026Article
- Antimicrobial resistance varies with warming in active layer soil and permafrost.Scientific reports · 2026Article
- The interplay between insect gut microbiota and host immunity in the development and dissemination of antibiotic resistance.Folia microbiologica · 2026Review
- Accumulation of antimicrobial resistance genes in wild chimpanzees.The ISME journal · 2026Article
- Article
- Antimicrobial potential of a new Streptomyces species isolated from a brazilian tropical coastal shrubland.Antonie van Leeuwenhoek · 2025Article
- "Dusting Off the Cobwebs": Rethinking How We Use New Antibiotics.Antibiotics (Basel, Switzerland) · 2025Review
- The Global Challenge of Antimicrobial Resistance: Mechanisms, Case Studies, and Mitigation Approaches.Health science reports · 2025Article
- Exploring molecular mechanisms of drug resistance in bacteria and progressions in CRISPR/Cas9-based genome expurgation solutions.Global medical genetics · 2025Review
- Antibiotic Abuse in Ornamental Fish: An Overlooked Reservoir for Antibiotic Resistance.Microorganisms · 2025Review
- Environmental drivers of the resistome across the Baltic Sea.Microbiome · 2025Article
- Role of Lysogenic Phages in the Dissemination of Antibiotic Resistance Genes Applied in the Food Chain.Foods (Basel, Switzerland) · 2025Review
- Characterization of antibiotic determinants and heavy metal resistance genes inMicrobial genomics · 2025Article
- Insight into the phylogeny and antibiotic resistance ofFrontiers in microbiology · 2025Article
- Longitudinal metagenomics reveals continuous restructuring of soil pathobiome under persistentFrontiers in plant science · 2025Article
- Discovery of New Natural Phytocompounds: The Modern Tools to Fight Against Traditional Bacterial Pathogens.Current pharmaceutical biotechnology · 2025Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance is an ancient problem, owing to the co-evolution of antibiotic-producing and target organisms in the soil and other environments over millennia. The environmental "resistome" is the collection of all genes that directly or indirectly contribute to antibiotic resistance. Many of these resistance determinants originate in antibiotic-producing organisms (where they serve to mediate self-immunity), while others become resistance determinants only when mobilized and over-expressed in non-native hosts (like plasmid-encoded β-lactamases). The modern environmental resistome is under selective pressure from human activities such as agriculture, which may influence the composition of the local resistome and lead to gene transfer events. Beyond the environment, we are challenged in the clinic by the rise in both frequency and diversity of antibiotic resistant pathogens. We assume that clinical resistance originated in the environment, but few examples of direct gene exchange between the environmental resistome and the clinical resistome have been documented. Strong evidence exists to suggest that clinical aminoglycoside and vancomycin resistance enzymes, the extended-spectrum β-lactamase CTX-M and the quinolone resistance gene qnr have direct links to the environmental resistome. In this review, we highlight recent advances in our understanding of horizontal gene transfer of antibiotic resistance genes from the environment to the clinic. Improvements in sequencing technologies coupled with functional metagenomic studies have revealed previously underappreciated diversity in the environmental resistome, and also established novel genetic links to the clinic. Understanding mechanisms of gene exchange becomes vital in controlling the future dissemination of antibiotic resistance.
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