ArticleFrontiers in neurology2013
Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects.
Article in Frontiers in neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 117 citations in OpenAlex.
- Focused ultrasound-induced cavitation in a human brain microphysiological system produces injury signaling biomarkers consistent with blast trauma.npj biomedical innovations · 2026Article
- Comparison of explosively driven shock tube and open-air blast wave propagation.Scientific reports · 2026Article
- Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures.Frontiers in bioengineering and biotechnology · 2025Review
- Numerical Investigation of the Blast-Induced Injuries Using an Open-Source Detailed Human Model.International journal for numerical methods in biomedical engineering · 2024Article
- Spatial Intracranial Pressure Fields Driven by Blast Overpressure in Rats.Annals of biomedical engineering · 2024Article
- Mathematical model of mechanobiology of acute and repeated synaptic injury and systemic biomarker kinetics.Frontiers in cellular neuroscience · 2023Article
- Editorial: New technologies and statistical models applied to sports and exercise science research: methodological, technical and practical considerations.Frontiers in sports and active living · 2023Article
- Understanding Primary Blast Injury: High Frequency Pressure Acutely Disrupts Neuronal Network Dynamics in Cerebral Organoids.Journal of neurotrauma · 2022Article
- Revealing the Effect of Skull Deformation on Intracranial Pressure Variation During the Direct Interaction Between Blast Wave and Surrogate Head.Annals of biomedical engineering · 2022Article
- Testing the blast response of foam inserts for helmets.Heliyon · 2021Article
- Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets.Journal of neuropathology and experimental neurology · 2021Article
- Cerebrospinal Fluid Cavitation as a Mechanism of Blast-Induced Traumatic Brain Injury: A Review of Current Debates, Methods, and Findings.Frontiers in neurology · 2021Review
- Role of Interfacial Conditions on Blast Overpressure Propagation Into the Brain.Frontiers in neurology · 2020Article
- Modelling traumatic brain injury and posttraumatic epilepsy in rodents.Neurobiology of disease · 2019Review
- Blast-Related Traumatic Brain Injury: Current Concepts and Research Considerations.Journal of experimental neuroscience · 2019Review
- Impact & Blast Traumatic Brain Injury: Implications for Therapy.Molecules (Basel, Switzerland) · 2018Review
- Computational modeling of drug transport across the in vitro cornea.Computers in biology and medicine · 2018Article
- Article
- Combination Therapy for Multi-Target Manipulation of Secondary Brain Injury Mechanisms.Current neuropharmacology · 2018Review
- Understanding blast-induced neurotrauma: how far have we come?Concussion (London, England) · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military activities and is the leading cause of death and long-term disability among U.S. soldiers. The current limited understanding of brain injury mechanisms impedes the development of protection, diagnostic, and treatment strategies. We believe mathematical models of blast wave brain injury biomechanics and neurobiology, complemented with in vitro and in vivo experimental studies, will enable a better understanding of injury mechanisms and accelerate the development of both protective and treatment strategies. The goal of this paper is to review the current state of the art in mathematical and computational modeling of blast-induced TBI, identify research gaps, and recommend future developments. A brief overview of blast wave physics, injury biomechanics, and the neurobiology of brain injury is used as a foundation for a more detailed discussion of multiscale mathematical models of primary biomechanics and secondary injury and repair mechanisms. The paper also presents a discussion of model development strategies, experimental approaches to generate benchmark data for model validation, and potential applications of the model for prevention and protection against blast wave TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.