ArticleFrontiers in psychology2013
The coherent organization of mental life depends on mechanisms for context-sensitive gain-control that are impaired in schizophrenia.
Article in Frontiers in psychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- Visual suppression deficits as a biomarker of working memory impairment in schizophrenia.Schizophrenia research. Cognition · 2026Review
- Impaired Contour Object Perception in Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Glutamate, Contextual Insensitivity, and Disorganized Speech in First-Episode Schizophrenia: A 7T Magnetic Resonance Spectroscopy Study.Biological psychiatry global open science · 2025Article
- Eye Movements During Pareidolia: Exploring Biomarkers for Thinking and Perception Problems on the Rorschach.Journal of eye movement research · 2025Article
- Altered Use of Context During Visual Perception in Psychotic Psychopathology: A Neurophysiological Investigation of Tuned and Untuned Suppression During Contrast Perception.Schizophrenia bulletin · 2024Article
- Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia.Scientific reports · 2024Article
- Impaired contour object perception in psychosis.medRxiv : the preprint server for health sciences · 2024Article
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- The psychosis human connectome project: Design and rationale for studies of visual neurophysiology.NeuroImage · 2023Article
- Divisive normalization unifies disparate response signatures throughout the human visual hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- N-methyl d-aspartate receptor hypofunction reduces visual contextual integration.Journal of vision · 2021Article
- Conscious Multisensory Integration: Introducing a Universal Contextual Field in Biological and Deep Artificial Neural Networks.Frontiers in computational neuroscience · 2020Article
- Transdiagnostic Multimodal Neuroimaging in Psychosis: Structural, Resting-State, and Task Magnetic Resonance Imaging Correlates of Cognitive Control.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- A review of visual aftereffects in schizophrenia.Neuroscience and biobehavioral reviews · 2019Review
- Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology.Frontiers in computational neuroscience · 2019Article
- Altered selection during language processing in individuals at high risk for psychosis.Schizophrenia research · 2018Article
- Data gathering ability contributes to visual organization and probabilistic reasoning.Heliyon · 2018Article
- Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State.Frontiers in neural circuits · 2018Review
- Implications of Information Theory for Computational Modeling of Schizophrenia.Computational psychiatry (Cambridge, Mass.) · 2017Article
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2 authors.
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Abstract
There is rapidly growing evidence that schizophrenia involves changes in context-sensitive gain-control and probabilistic inference. In addition to the well-known cognitive disorganization to which these changes lead, basic aspects of vision are also impaired, as discussed by other papers on this Frontiers Research Topic. The aim of this paper is to contribute to our understanding of such findings by examining five central hypotheses. First, context-sensitive gain-control is fundamental to brain function and mental life. Second, it occurs in many different regions of the cerebral cortex of many different mammalian species. Third, it has several computational functions, each with wide generality. Fourth, it is implemented by several neural mechanisms at cellular and circuit levels. Fifth, impairments of context-sensitive gain-control produce many of the well-known symptoms of schizophrenia and change basic processes of visual perception. These hypotheses suggest why disorders of vision in schizophrenia may provide insights into the nature and mechanisms of impaired reality testing and thought disorder in psychosis. They may also cast light on normal mental function and its neural bases. Limitations of these hypotheses, and ways in which they need further testing and development, are outlined.
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