ArticleFrontiers in neuroenergetics2013
Glucose and lactate metabolism in the awake and stimulated rat: a (13)C-NMR study.
Article in Frontiers in neuroenergetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila.Nature metabolism · 2023Article
- Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging.Nature communications · 2023Article
- Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion.Research square · 2023Article
- Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neuroprotective role of lactate in rat neonatal hypoxia-ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Voluntary Behavior and Training Conditions ModulateFrontiers in neuroscience · 2021Article
- NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection.Tuberculosis (Edinburgh, Scotland) · 2021Article
- Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle.Neuron · 2017Article
- Lactate Shuttles in Neuroenergetics-Homeostasis, Allostasis and Beyond.Frontiers in neuroscience · 2017Review
- Article
- Neurometabolic coupling between neural activity, glucose, and lactate in activated visual cortex.Journal of neurochemistry · 2015Article
- Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: an integrated study using (1)H- and (13)C-NMR spectroscopy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings.Metabolic brain disease · 2015Review
- Editorial: "Transcellular Cycles Underlying Neurotransmission".Frontiers in nutrition · 2015Article
- Forgetfulness during aging: an integrated biology.Neurobiology of learning and memory · 2014Review
- Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work.Frontiers in neuroscience · 2014Article
- (13)C NMR spectroscopy applications to brain energy metabolism.Frontiers in neuroenergetics · 2013Review
- Modulation of multiple memory systems: from neurotransmitters to metabolic substrates.Hippocampus · 2013Review
- Unraveling the complex metabolic nature of astrocytes.Frontiers in cellular neuroscience · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose is the major energetic substrate for the brain but evidence has accumulated during the last 20 years that lactate produced by astrocytes could be an additional substrate for neurons. However, little information exists about this lactate shuttle in vivo in activated and awake animals. We designed an experiment in which the cortical barrel field (S1BF) was unilaterally activated during infusion of both glucose and lactate (alternatively labeled with (13)C) in rats. At the end of stimulation (1 h) both S1BF areas were removed and analyzed by HR-MAS NMR spectroscopy to compare glucose and lactate metabolism in the activated area vs. the non-activated one. In combination with microwave irradiation HR-MAS spectroscopy is a powerful technical approach to study brain lactate metabolism in vivo. Using in vivo (14)C-2-deoxyglucose and autoradiography we confirmed that whisker stimulation was effective since we observed a 40% increase in glucose uptake in the activated S1BF area compared to the ipsilateral one. We first determined that lactate observed on spectra of biopsies did not arise from post-mortem metabolism. (1)H-NMR data indicated that during brain activation there was an average 2.4-fold increase in lactate content in the activated area. When [1-(13)C]glucose + lactate were infused (13)C-NMR data showed an increase in (13)C-labeled lactate during brain activation as well as an increase in lactate C3-specific enrichment. This result demonstrates that the increase in lactate observed on (1)H-NMR spectra originates from newly synthesized lactate from the labeled precursor ([1-(13)C]glucose). It also shows that this additional lactate does not arise from an increase in blood lactate uptake since it would otherwise be unlabeled. These results are in favor of intracerebral lactate production during brain activation in vivo which could be a supplementary fuel for neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.