ArticlePLoS genetics2013
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
Open access · goldAbstract read
In one paragraph
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers, 18 of them syntheses that pooled it.
0numbers the graph read from it
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272citing papers in PubMed, 18 pooled it
28.1field-weighted citation impact, top 1% of its field
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Who cites it
272 citing papers in PubMed, 18 syntheses or guidelines pooled it, 456 citations in OpenAlex.
- Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.Nature communications · 2024Pooled it
- Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.Nature genetics · 2023Pooled it
- Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex.EBioMedicine · 2023Pooled it
- X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.Respiratory research · 2023Pooled it
- Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.Communications biology · 2022Pooled it
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.Communications biology · 2022Pooled it
- Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank.PLoS genetics · 2021Pooled it
- Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.Nature communications · 2021Pooled it
- Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.Nature communications · 2020Pooled it
- Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.Human molecular genetics · 2019Pooled it
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.American journal of human genetics · 2018Pooled it
- Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.Nature communications · 2018Pooled it
- Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.American journal of respiratory cell and molecular biology · 2018Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.PLoS genetics · 2017Pooled it
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.Nature communications · 2017Pooled it
- Genetic invalidation of Lp-PLAEuropean journal of preventive cardiology · 2017Pooled it
- Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.International journal of obesity (2005) · 2017Pooled it
- Prenatal social support in low-risk pregnancy shapes placental epigenome.BMC medicine · 2023Trial
- AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.Molecular and cellular endocrinology · 2021Trial
212 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
266 authors at 20 institutions in 17 countries.
Joshua C RandallWellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
Thomas W Winkler
Zoltán Kutalik
Sonja I Berndt
Anne U Jackson
Keri L Monda
Tuomas O Kilpeläinen
Tõnu Esko
Reedik Mägi
Shengxu Li
Tsegaselassie Workalemahu
Mary F Feitosa
Damien C Croteau-Chonka
Felix R Day
Tove Fall
Teresa Ferreira
Stefan Gustafsson
Adam E Locke
Iain Mathieson
Andre Scherag
Sailaja Vedantam
Andrew R Wood
Liming Liang
Valgerdur Steinthorsdottir
Gudmar Thorleifsson
Emmanouil T Dermitzakis
Antigone S Dimas
Fredrik Karpe
Josine L Min
George Nicholson
Deborah J Clegg
Thomas Person
Jon P Krohn
Sabrina Bauer
Christa Buechler
Kristina Eisinger
DIAGRAM Consortium
Amélie Bonnefond
Philippe Froguel
MAGIC Investigators
Jouke-Jan Hottenga
Inga Prokopenko
Lindsay L Waite
Tamara B Harris
Albert Vernon Smith
Alan R Shuldiner
Wendy L McArdle
Mark J Caulfield
Patricia B Munroe
Henrik Grönberg
Yii-Der Ida Chen
Guo Li
Jacques S Beckmann
Toby Johnson
Unnur Thorsteinsdottir
Maris Teder-Laving
Kay-Tee Khaw
Nicholas J Wareham
Jing Hua Zhao
Najaf Amin
Ben A Oostra
Aldi T Kraja
Michael A Province
L Adrienne Cupples
Nancy L Heard-Costa
Jaakko Kaprio
Samuli Ripatti
Ida Surakka
Francis S Collins
Jouko Saramies
Jaakko Tuomilehto
Antti Jula
Veikko Salomaa
Jeanette Erdmann
Christian Hengstenberg
Christina Loley
Heribert Schunkert
Claudia Lamina
H Erich Wichmann
Eva Albrecht
Christian Gieger
Andrew A Hicks
Asa Johansson
Peter P Pramstaller
Sekar Kathiresan
Elizabeth K Speliotes
Brenda Penninx
Anna-Liisa Hartikainen
Marjo-Riitta Jarvelin
Ulf Gyllensten
Dorret I Boomsma
Harry Campbell
James F Wilson
Stephen J Chanock
Martin Farrall
Anuj Goel
Carolina Medina-Gomez
Fernando Rivadeneira
Karol Estrada
André G Uitterlinden
Albert Hofman
M Carola Zillikens
Martin den Heijer
Lambertus A Kiemeney
Andrea Maschio
Per Hall
Jonathan Tyrer
Alexander Teumer
Henry Völzke
Peter Kovacs
Anke Tönjes
Massimo Mangino
Tim D Spector
Caroline Hayward
Igor Rudan
Alistair S Hall
Nilesh J Samani
Antony Paul Attwood
Jennifer G Sambrook
Joseph Hung
Lyle J Palmer
Marja-Liisa Lokki
Juha Sinisalo
Gabrielle Boucher
Heikki Huikuri
Mattias Lorentzon
Claes Ohlsson
Niina Eklund
Johan G Eriksson
Cristina Barlassina
Carlo Rivolta
Ilja M Nolte
Harold Snieder
Melanie M Van der Klauw
Jana V Van Vliet-Ostaptchouk
Pablo V Gejman
Jianxin Shi
Kevin B Jacobs
Zhaoming Wang
Stephan J L Bakker
Irene Mateo Leach
Gerjan Navis
Pim van der Harst
Nicholas G Martin
Sarah E Medland
Grant W Montgomery
Jian Yang
Daniel I Chasman
Paul M Ridker
Lynda M Rose
Terho Lehtimäki
Olli Raitakari
Devin Absher
Carlos Iribarren
Hanneke Basart
Kees G Hovingh
Elina Hyppönen
Chris Power
Denise Anderson
John P Beilby
Jennie Hui
Jennifer Jolley
Hendrik Sager
Stefan R Bornstein
Peter E H Schwarz
Kati Kristiansson
Markus Perola
Jaana Lindström
Amy J Swift
Matti Uusitupa
Mustafa Atalay
Timo A Lakka
Rainer Rauramaa
Jennifer L Bolton
Gerry Fowkes
Ross M Fraser
Jackie F Price
Krista Fischer
Kaarel Krjutå Kov
Andres Metspalu
Evelin Mihailov
Claudia Langenberg
Jian'an Luan
Ken K Ong
Peter S Chines
Sirkka M Keinanen-Kiukaanniemi
Timo E Saaristo
Sarah Edkins
Paul W Franks
Göran Hallmans
Dmitry Shungin
Andrew David Morris
Colin N A Palmer
Raimund Erbel
Susanne Moebus
Markus M Nöthen
Sonali Pechlivanis
Kristian Hveem
Narisu Narisu
Anders Hamsten
Steve E Humphries
Rona J Strawbridge
Elena Tremoli
Harald Grallert
Barbara Thorand
Thomas Illig
Wolfgang Koenig
Martina Müller-Nurasyid
Annette Peters
Bernhard O Boehm
Marcus E Kleber
Winfried März
Bernhard R Winkelmann
Johanna Kuusisto
Markku Laakso
Dominique Arveiler
Giancarlo Cesana
Kari Kuulasmaa
Jarmo Virtamo
John W G Yarnell
Diana Kuh
Andrew Wong
Lars Lind
Ulf de Faire
Bruna Gigante
Patrik K E Magnusson
Nancy L Pedersen
George Dedoussis
Maria Dimitriou
Genovefa Kolovou
Stavroula Kanoni
Kathleen Stirrups
Lori L Bonnycastle
Inger Njølstad
Tom Wilsgaard
Andrea Ganna
Emil Rehnberg
Aroon Hingorani
Mika Kivimaki
Meena Kumari
Themistocles L Assimes
Inês Barroso
Michael Boehnke
Ingrid B Borecki
Panos Deloukas
Caroline S Fox
Timothy Frayling
Leif C Groop
Talin Haritunians
David Hunter
Erik Ingelsson
Robert Kaplan
Karen L Mohlke
Jeffrey R O'Connell
David Schlessinger
David P Strachan
Kari Stefansson
Cornelia M van Duijn
Gonçalo R Abecasis
Mark I McCarthy
Joel N Hirschhorn
Lu Qi
Ruth J F Loos
Cecilia M Lindgren
Kari E North
Iris M Heid
University of North Carolina at Chapel Hill · USBroad Institute · USCentre for Human Genetics · GBHarvard University · USBoston Children's Hospital · USKarolinska Institutet · SEErasmus MC · NLUniversity Medical Center Groningen · NLUniversity of Helsinki · FIWashington University in St. Louis · USAddenbrooke's Hospital · GBFinnish Institute for Health and Welfare · FIHelmholtz Zentrum München · DEUniversity of Tartu · EEdeCODE Genetics (Iceland) · ISNational Human Genome Research Institute · USNational Institutes of Health · USBrigham and Women's Hospital · USUniversity of Cambridge · GBWellcome Sanger Institute · GB
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MRisk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MPharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MAHRQ HHS R01HS006516British Heart Foundation PG/07/133/24260British Heart Foundation RG/08/008/25291Cancer Research UK 14136Cancer Research UK C490/A10124Cancer Research UK C490/A8339Chief Scientist Office CZB/4/672Chief Scientist Office CZB/4/710CSR NIH HHS RG2008/014CSR NIH HHS RG2008/08Intramural NIH HHS Z01 HG000024Medical Research Council 85374Medical Research Council G0000649Medical Research Council G0000934Medical Research Council G0401527Medical Research Council G0500539Medical Research Council G0600237Medical Research Council G0600705Medical Research Council G0601261Medical Research Council G1000143Medical Research Council G1002084Medical Research Council G9521010Medical Research Council G9521010DMedical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_U106188470Medical Research Council MC_U123092720Medical Research Council MC_UU_12015/2Medical Research Council MR/K006584/1NCATS NIH 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Abstract
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10(-8)), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits.
Indexed as
Body Weights and MeasuresGenome-Wide Association StudySex CharacteristicsAnthropometryBody HeightBody Mass IndexBody WeightFemaleGenetic LociGenome, HumanHumansMalePolymorphism, Single NucleotideWaist CircumferenceWaist-Hip Ratio
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