ArticleNucleic acids research2013
The genetic code constrains yet facilitates Darwinian evolution.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Nucleic acid recognition during prokaryotic immunity.Molecular cell · 2025Review
- Robust genetic codes enhance protein evolvability.PLoS biology · 2024Article
- Self-similarity and the maximum entropy principle in the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes.Nature communications · 2022Article
- Highly efficient libraries design for saturation mutagenesis.Synthetic biology (Oxford, England) · 2022Article
- Predicting Drug Resistance Using Deep Mutational Scanning.Molecules (Basel, Switzerland) · 2020Review
- Accelerating structure-function mapping using the ViVa webtool to mine natural variation.Plant direct · 2019Article
- Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E. coli.ACS synthetic biology · 2018Article
- The Standard Genetic Code Facilitates Exploration of the Space of Functional Nucleotide Sequences.Journal of molecular evolution · 2018Article
- The Bioactivity of D-/L-Isonucleoside- and 2'-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression.Molecular therapy. Nucleic acids · 2017Article
- Article
- Environmental changes bridge evolutionary valleys.Science advances · 2016Article
- Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination.PLoS genetics · 2015Article
- A comprehensive, high-resolution map of a gene's fitness landscape.Molecular biology and evolution · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important goal of evolutionary biology is to understand the constraints that shape the dynamics and outcomes of evolution. Here, we address the extent to which the structure of the standard genetic code constrains evolution by analyzing adaptive mutations of the antibiotic resistance gene TEM-1 β-lactamase and the fitness distribution of codon substitutions in two influenza hemagglutinin inhibitor genes. We find that the architecture of the genetic code significantly constrains the adaptive exploration of sequence space. However, the constraints endow the code with two advantages: the ability to restrict access to amino acid mutations with a strong negative effect and, most remarkably, the ability to enrich for adaptive mutations. Our findings support the hypothesis that the standard genetic code was shaped by selective pressure to minimize the deleterious effects of mutation yet facilitate the evolution of proteins through imposing an adaptive mutation bias.
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