ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Controlling the delicate balance of tetrapyrrole biosynthesis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Response of Hemolytic and Photosynthetic Activity ofToxins · 2026Article
- The Impact of the Major Endoribonucleases RNase E and RNase III and of the sRNA StsR on Photosynthesis Gene Expression inInternational journal of molecular sciences · 2024Article
- Glutamate 1-semialdehyde aminotransferase is connected to GluTR by GluTR-binding protein and contributes to the rate-limiting step of 5-aminolevulinic acid synthesis.The Plant cell · 2022Article
- The small DUF1127 protein CcaF1 from Rhodobacter sphaeroides is an RNA-binding protein involved in sRNA maturation and RNA turnover.Nucleic acids research · 2021Article
- Heterologous expression of cobalamin dependent class-III enzymes.Protein expression and purification · 2021Article
- Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies.Microbial cell factories · 2020Article
- Rhodobacterales use a unique L-threonine kinase for the assembly of the nucleotide loop of coenzyme BMolecular microbiology · 2018Article
- Characterization of the complex between native and reduced bovine serum albumin with aquacobalamin and evidence of dual tetrapyrrole binding.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Article
- Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease.Infection and immunity · 2018Article
- Design and validation of an open-source modular Microplate Photoirradiation System for high-throughput photobiology experiments.PloS one · 2018Article
- Systematic bacterialization of yeast genes identifies a near-universally swappable pathway.eLife · 2017Article
- A New Facet of Vitamin BAnnual review of biochemistry · 2017Review
- Gametophyte Development Needs Mitochondrial Coproporphyrinogen III Oxidase Function.Plant physiology · 2017Article
- The Vitamin BmBio · 2017Article
- Microbial production of vitamin BMicrobial cell factories · 2017Review
- The Remarkable Character of Porphobilinogen Synthase.Accounts of chemical research · 2016Article
- Cobalamin's (Vitamin B12) Surprising Function as a Photoreceptor.Trends in biochemical sciences · 2016Article
- In Vitro Optimization of Enzymes Involved in Precorrin-2 Synthesis Using Response Surface Methodology.PloS one · 2016Article
- Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian.Cell discovery · 2016Article
- Plant Protochlorophyllide Oxidoreductases A and B: CATALYTIC EFFICIENCY AND INITIAL REACTION STEPS.The Journal of biological chemistry · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Tetrapyrroles are a family of compounds that contain four pyrrole rings. They are involved in many fundamental biological processes such as photoreception, electron transport, gas transport and also as cofactors for enzymatic reactions. As regulators of protein activity, tetrapyrroles mediate cellular response to light, oxygen and nutrient levels in the surrounding environment. Biosynthesis of haem tetrapyrroles shares, conserved pathways and enzymes among all three domains of life. This is contrasted by chlorophyll biosynthesis that is only present in eubacteria and chloroplasts, or cobalamin biosynthesis that is only present in eubacteria and archaea. This implicates haem as the most ancient, and chlorophyll as the most recent, of the common tetrapyrroles that are currently synthesized by existing organisms. Haem and chlorophyll are both toxic when synthesized in excess over apo-proteins that bind these tetrapyrroles. Accordingly, the synthesis of these tetrapyrroles has to be tightly regulated and coordinated with apo-protein production. The mechanism of regulating haem and chlorophyll synthesis has been studied intensively in Rhodobacter species and will be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.