ArticleJournal of neurology2013
Grey and white matter abnormalities in temporal lobe epilepsy with and without mesial temporal sclerosis.
Article in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450822 (The BrainDrugs-Epilepsy Study), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis.NeuroImage. Clinical · 2016Pooled it
- Splenial lesions of the corpus callosum: a comprehensive study on etiology, clinical presentation, radiological features, and prognostic insights.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Microstructural Analysis of Whole-Brain Changes Increases the Detection of Pediatric Focal Cortical Dysplasia.Diagnostics (Basel, Switzerland) · 2025Article
- Altered structural network in temporal lobe epilepsy with focal to bilateral tonic-clonic seizures.Annals of clinical and translational neurology · 2024Article
- Simultaneous high-resolution whole-brain MR spectroscopy and [European journal of nuclear medicine and molecular imaging · 2024Article
- Hippocampal microscopic fractional anisotropy is reduced in temporal lobe epilepsy.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Progressive generalized tonic-clonic seizures in a transgenic mouse model of adult-onset epilepsy: Implications for morphological changes in cortico-limbic and brainstem structures.Epilepsy research · 2023Article
- Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging.Brain and behavior · 2023Article
- The BrainDrugs-epilepsy study: A prospective open-label cohort precision medicine study in epilepsy.Neuroscience applied · 2023Article
- Cortical thickness analysis in temporal lobe epilepsy using fully Bayesian spectral method in magnetic resonance imaging.BMC medical imaging · 2022Article
- Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy.Science advances · 2022Article
- High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy.Acta neuropathologica communications · 2022Article
- Dynamic functional connectivity in modular organization of the hippocampal network marks memory phenotypes in temporal lobe epilepsy.Human brain mapping · 2022Article
- Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system xJournal of neuroscience research · 2021Article
- The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Lateralizing the affected side of hippocampal sclerosis with quantitative high angular resolution diffusion scalars: a preliminary approach validated by diffusion spectrum imaging.Annals of translational medicine · 2021Article
- Prospective Quantitative Neuroimaging Analysis of Putative Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging.Frontiers of medicine · 2020Article
- From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod.Current neuropharmacology · 2020Review
- NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Temporal lobe epilepsy with (TLE-mts) and without (TLE-no) mesial temporal sclerosis display different patterns of cortical neuronal loss, suggesting that the distribution of white matter damage may also differ between the sub-groups. The purpose of this study was to examine patterns of white matter damage in TLE-mts and TLE-no and to determine if identified changes are related to neuronal loss at the presumed seizure focus. The 4 T diffusion tensor imaging (DTI) and T1-weighted data were acquired for 22 TLE-mts, 21 TLE-no and 31 healthy controls. Tract-based spatial statistics (TBSS) was used to compare fractional anisotropy (FA) maps and voxel-based morphometry (VBM) was used to identify grey matter (GM) volume atrophy. Correlation analysis was conducted between the FA maps and neuronal loss at the presumed seizure focus. In TLE-mts, reduced FA was identified in the genu, body and splenium of the corpus callosum, bilateral corona radiata, cingulum, external capsule, ipsilateral internal capsule and uncinate fasciculus. In TLE-no, FA decreases were identified in the genu, the body of the corpus callosum and ipsilateral anterior corona radiata. The FA positively correlated with ipsilateral hippocampal volume. Widespread extra-focal GM atrophy was associated with both sub-groups. Despite widespread and extensive GM atrophy displaying different anatomical patterns in both sub-groups, TLE-mts demonstrated more extensive FA abnormalities than TLE-no. The microstructural organization in the corpus callosum was related to hippocampal volume in both patients and healthy subjects demonstrating the association of these distal regions.
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Registered trials
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