ReviewWiley interdisciplinary reviews. RNA
Non-mRNA 3' end formation: how the other half lives.
Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- SnoRNAs: Exploring Their Implication in Human Diseases.International journal of molecular sciences · 2024Review
- Generation ofDevelopment & reproduction · 2023Article
- Mutations in the non-coding RNU4ATAC gene affect the homeostasis and function of the Integrator complex.Nucleic acids research · 2023Article
- The Integrator complex at the crossroad of coding and noncoding RNA.Current opinion in cell biology · 2021Review
- The Integrator Complex in Transcription and Development.Trends in biochemical sciences · 2020Review
- INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.Nature communications · 2020Article
- The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea.PLoS genetics · 2018Article
- Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.Nucleic acids research · 2018Article
- Circular RNAs: Unexpected outputs of many protein-coding genes.RNA biology · 2017Review
- Human mutations in integrator complex subunits link transcriptome integrity to brain development.PLoS genetics · 2017Article
- snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis.PLoS biology · 2016Article
- Long noncoding RNAs: Re-writing dogmas of RNA processing and stability.Biochimica et biophysica acta · 2016Review
- Integrator: surprisingly diverse functions in gene expression.Trends in biochemical sciences · 2015Review
- mRNA maturation in giant viruses: variation on a theme.Nucleic acids research · 2015Article
- Long non-coding RNAs in cancer and development: where do we go from here?International journal of molecular sciences · 2015Review
- Integrator regulates transcriptional initiation and pause release following activation.Molecular cell · 2014Article
- The interplay of long non-coding RNAs and MYC in cancer.AIMS biophysicsArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
The release of nascent RNA from transcribing RNA polymerase complexes is required for all further functions carried out by RNA molecules. The elements and processing machinery involved in 3' end formation therefore represent key determinants in the biogenesis and accumulation of cellular RNA. While these factors have been well-characterized for messenger RNA, recent work has elucidated analogous pathways for the 3' end formation of other important cellular RNA. Here, we discuss four specific cases of non-mRNA 3' end formation-metazoan small nuclear RNA, Saccharomyces cerevisiae small nuclear RNA, Schizosaccharomyces pombe telomerase RNA, and the mammalian MALAT1 large noncoding RNA-as models of alternative mechanisms to generate RNA 3' ends. Comparison of these disparate processing pathways reveals an emerging theme of evolutionary ingenuity. In some instances, evidence for the creation of a dedicated processing complex exists; while in others, components are utilized from the existing RNA processing machinery and modified to custom fit the unique needs of the RNA substrate. Regardless of the details of how non-mRNA 3' ends are formed, the lengths to which biological systems will go to release nascent transcripts from their DNA templates are fundamental for cell survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.