ArticleMolecular and cellular biochemistry2013
siRNA-mediated knockdown of SMC1A expression suppresses the proliferation of glioblastoma cells.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression.PloS one · 2016Pooled it
- Bioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperformingTherapeutic advances in medical oncology · 2024Article
- Effects of SMC1A on immune microenvironment and cancer stem cells in colon adenocarcinoma.Cancer medicine · 2023Article
- The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.Science advances · 2021Article
- Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier.Frontiers in medical technology · 2021Review
- Article
- Knockdown of lncRNA TUG1 Enhances Radiosensitivity of Prostate Cancer via the TUG1/miR-139-5p/SMC1A Axis.OncoTargets and therapy · 2020Article
- Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration.International journal of biological sciences · 2018Article
- Clinicopathologic and molecular characterization of myeloid neoplasms with isolated t(6;9)(p23;q34).International journal of laboratory hematology · 2017Article
- Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis.International journal of biological sciences · 2017Review
- miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells.Aging · 2016Article
- Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer.Journal of translational medicine · 2015Article
- Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer.BMC cancer · 2015Article
- Tumor protein D52-like 2 contributes to proliferation of breast cancer cells.Cancer biotherapy & radiopharmaceuticals · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SMC1A is a member of cohesin complex which has essential functions in cell cycle progression and DNA repair. Therefore, we choose SMC1A as a target gene therapy of glioblastoma. It is well known that glioblastoma has very low survival rate because of ineffectiveness of conventional treatments. This study was designed to explore the possibilities of small interfering RNA (siRNA)-mediated SMC1A silencing as alternative method of treatment. We found that the lentivirus-mediated RNAi system efficiently decreased the expression level of SMC1A. Inhibiting SMC1A expression efficiently (P < 0.001) resulted in inhibiting the proliferation and colony formation of U251 and U87MG cells. Moreover, we found that SMC1A silencing led to S cell-cycle arresting. Collectively, these results demonstrated the possibility of siRNA-mediated silencing of SMC1A as a therapeutic tool for the treatment of glioblastoma.
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Registered trials
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