ArticleProceedings of the National Academy of Sciences of the United States of America2013
Making lasting memories: remembering the significant.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Highly Superior Autobiographical Memory (HSAM): A Systematic Review.Neuropsychology review · 2025Pooled it
- Impairing memory reconsolidation with propranolol in healthy and clinical samples: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear.The international journal of neuropsychopharmacology · 2022Trial
- What makes music memorable? Relationships between acoustic musical features and music-evoked emotions and memories in older adults.PloS one · 2021Trial
- Enhanced brain activity associated with memory access in highly superior autobiographical memory.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Direct electrical stimulation of the amygdala enhances declarative memory in humans.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Noradrenergic mechanisms of arousal's bidirectional effects on episodic memory.Neurobiology of learning and memory · 2017Trial
- Consumer and health professional reflections and feedback on the Help After Leaving hospiTal delirium rehabilitation programme.Age and ageing · 2026Article
- Signaling Connectomics: A Brain-wide Framework for Intercellular Communication.Experimental neurobiology · 2026Article
- Communicator and collaborator - a Finnish national repeated cross-sectional survey of the two CanMEDS competencies by specialty group.BMC medical education · 2026Article
- Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.Communications biology · 2026Article
- Retention and transformation of internal experiences in autobiographical memory narratives.Communications psychology · 2026Article
- Comparative effects of intermittent theta-burst stimulation and sequential bilateral rTMS on depression and emotion regulation in major depressive disorder: a randomized controlled trial.Frontiers in neuroscience · 2026Article
- Sleep neuroimaging: Review and future directions.Journal of sleep research · 2025Review
- Article
- Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.bioRxiv : the preprint server for biology · 2025Article
- Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus.bioRxiv : the preprint server for biology · 2025Article
- Social buffering during fear extinction rescues long-term trauma-induced memory and emotional behavioral alterations in rats.Translational psychiatry · 2025Article
- Exploring individual differences in amygdala-mediated memory modulation.Cognitive, affective & behavioral neuroscience · 2025Article
- Tell me why: the missing w in episodic memory's what, where, and when.Cognitive, affective & behavioral neuroscience · 2025Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Although forgetting is the common fate of most of our experiences, much evidence indicates that emotional arousal enhances the storage of memories, thus serving to create, selectively, lasting memories of our more important experiences. The neurobiological systems mediating emotional arousal and memory are very closely linked. The adrenal stress hormones epinephrine and corticosterone released by emotional arousal regulate the consolidation of long-term memory. The amygdala plays a critical role in mediating these stress hormone influences. The release of norepinephrine in the amygdala and the activation of noradrenergic receptors are essential for stress hormone-induced memory enhancement. The findings of both animal and human studies provide compelling evidence that stress-induced activation of the amygdala and its interactions with other brain regions involved in processing memory play a critical role in ensuring that emotionally significant experiences are well-remembered. Recent research has determined that some human subjects have highly superior autobiographic memory of their daily experiences and that there are structural differences in the brains of these subjects compared with the brains of subjects who do not have such memory. Understanding of neurobiological bases of such exceptional memory may provide additional insights into the processes underlying the selectivity of memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.