ArticleLipids2013
Identification of cyclopropaneoctanoic acid 2-hexyl in human adipose tissue and serum.
Article in Lipids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03612700 (Presence of Cyclopropane Fatty Acids), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma After CPFA-rich Diet
Who cites it
15 citing papers in PubMed.
- Identification of Cyclopropane Fatty Acids in Human Plasma after Controlled Dietary Intake of Specific Foods.Nutrients · 2020Trial
- Disorders of serum omega-3 fatty acid composition in dialyzed patients, and their associations with fat mass.Renal failure · 2017Trial
- Effect of Diet on CPFAs Used as Markers in Milk for the Detection of Silage in the Ration of Dairy Cows.Foods (Basel, Switzerland) · 2025Article
- Branched-chain fatty acids affect the expression of fatty acid synthase and C-reactive protein genes in the hepatocyte cell line.Bioscience reports · 2023Article
- The Effects of One-Anastomosis Gastric Bypass on Fatty Acids in the Serum of Patients with Morbid Obesity.Obesity surgery · 2021Article
- Statement on additional scientific evidence in relation to the essential composition of total diet replacement for weight control.EFSA journal. European Food Safety Authority · 2021Article
- Sample Preparation Methods for Lipidomics Approaches Used in Studies of Obesity.Molecules (Basel, Switzerland) · 2020Review
- Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain.Nature communications · 2019Article
- Alterations of Fatty Acid Profile May Contribute to Dyslipidemia in Chronic Kidney Disease by Influencing Hepatocyte Metabolism.International journal of molecular sciences · 2019Article
- Exercise and Conjugated Linoleic Acid Supplementation Induce Changes in the Composition of Liver Fatty Acids.Frontiers in physiology · 2019Article
- Determination of Cyclopropane Fatty Acids in Food of Animal Origin byJournal of analytical methods in chemistry · 2018Article
- Application of Metabolomics to Study Effects of Bariatric Surgery.Journal of diabetes research · 2018Review
- Potential Application ofScientific reports · 2017Article
- Increased Serum Level of Cyclopropaneoctanoic Acid 2-Hexyl in Patients with Hypertriglyceridemia-Related Disorders.Lipids · 2016Article
- Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acids containing a cyclopropane ring in their structure (cyclopropane FA) have been found in a wide variety of bacteria, a number of protozoa, and Myriapoda. Little is known about cyclopropane FA in mammal, especially in human tissues. The present study deals with the identification of cyclopropane FA in adipose tissue and serum of humans and rats. Fatty acids extracted from the adipose tissue and serum obtained from obese women during bariatric surgery were methylated and analyzed on GC-MS. We have identified: cyclopropaneoctanoic acid 2-hexyl, cyclopropaneoctanoic acid 2-octyl, cyclopropanenonanoic acid, and 2-[[2-[(2-ethylcyclopropyl)methyl]cyclopropyl]methyl] acid in human adipose tissue. We confirmed the presence of cyclopropaneoctanoic acid 2-hexyl by derivatization of FA extracted from human adipose tissue to picolinyl esters. Cyclopropaneoctanoic acid 2-hexyl was the main cyclopropane FA (approximately 0.4 % of total fatty acids in human adipose tissue, and about 0.2 % of total fatty acids in the serum). In adipose tissue cyclopropaneoctanoic acid 2-hexyl was found mainly in triacylglycerols, whereas in serum in phospholipids and triacylglycerols. The cyclopropaneoctanoic acid 2-hexyl has also been found in serum, and adipose tissue of rats in amounts comparable to humans. The content of cyclopropaneoctanoic acid 2-hexyl decreased in adipose tissue of rats maintained on a restricted diet for 1 month. In conclusion, we demonstrated that cyclopropaneoctanoic acid 2-hexyl is present in human adipose tissue and serum. Adipose tissue cyclopropaneoctanoic acid 2-hexyl is stored mainly in triacylglycerols and the storage of this cyclopropane FA is affected by food restriction.
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