Evidence map›Paper›PMID 23754303›Full record

ArticleInternational journal of geriatric psychiatry2014

Serotonin transporter polymorphism is associated with increased apnea-hypopnea index in older adults.

Carmen M Schröder, Michelle M Primeau, Joachim F Hallmayer, Laura C Lazzeroni, Jeffrey T Hubbard, Ruth O'Hara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Effects of body mass index-related disorders on cognition: preliminary results.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Carmen M SchröderDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; Department of Psychiatry and Behavioral Sciences, Strasbourg University Hospital and Strasbourg University, Strasbourg, France; CNRS UPR 3212, Institute for Cellular and Integrative Neuroscience, Strasbourg, France; University Sleep Clinic, Department of Neurology, Strasbourg University Hospital, Strasbourg, France.
Michelle M Primeau
Joachim F Hallmayer
Laura C Lazzeroni
Jeffrey T Hubbard
Ruth O'Hara
Stanford University · USCentre National de la Recherche Scientifique · FR

Funding

Stress, The HPA and Health in AgingP01AG018784 · NIA · STANFORD UNIVERSITY · PI SPIEGEL, DAVID · 2001 to 2008
$8.7M
STANFORD ALZHEIMER'S DISEASE CORE CENTERP30AG017824 · NIA · STANFORD UNIVERSITY · PI YESAVAGE, JEROME A · 2000 to 2005
$5.3M
MCI, APOE and Sleep Apnea: Effects on CognitionR01MH070886 · NIMH · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2005 to 2009
$1.4M
NIA NIH HHS AG 17824NIA NIH HHS AG 18784NIA NIH HHS P01 AG018784NIA NIH HHS P30 AG017824NIMH NIH HHS MH 070886NIMH NIH HHS R01 MH070886
6 · The paper itself

Abstract

rationaleA functional polymorphism of the serotonin transporter gene (5-HTTLPR) has previously been related to upper airway pathology, but its contribution to obstructive sleep apnea (OSA), a highly prevalent sleep disorder in older adults, remains unclear.

objectivesWe aimed to investigate the relationship between apnea-hypopnea index (AHI) and genetic variations in the promoter region of the 5-HTTLPR in older adults.

methodsDNA samples from 94 community-dwelling older adults (57% female, mean age 72 ± 8) were genotyped for the 5-HTTLPR polymorphism. All participants were assessed in their homes with full ambulatory polysomnography in order to determine AHI and related parameters such as hypoxia, sleep fragmentation, and self-reported daytime sleepiness.

resultsThe 5-HTT l allele was significantly associated with AHI (p = 0.019), with l allele carriers displaying a higher AHI than s allele homozygotes. A single allele change in 5-HTTLPR genotype from s to l resulted in an increase of AHI by 4.46 per hour of sleep (95% CI, 0.75-8.17). The l allele was also associated with increased time during sleep spent at oxygen saturation levels below 90% (p = 0.014).

conclusionsThe observed significant association between the 5-HTTLPR l allele and severity of OSA in older adults suggests that the l allele may be important to consider when assessing for OSA in this age group. This association may also explain some of the observed variability among serotonergic pharmacological treatment studies for OSA, and 5-HTT genotype status may have to be taken into account in future therapeutic trials involving serotonergic agents.

Indexed as

Polymorphism, GeneticAgedAged, 80 and overAllelesFemaleGenotypeHumansMalePolysomnographyRegression AnalysisSerotonin Plasma Membrane Transport ProteinsSleep Apnea SyndromesSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human5-HTTLPRagingOSAsleepsleep apnea

Identifiers

PMID23754303
PMCPMC3883911
OpenAlexW2164260280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.